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Intranasal epidermal growth factor treatment rescues neonatal brain injury

Author

Listed:
  • Joseph Scafidi

    (Center for Neuroscience Research, Children’s National Medical Center
    Children’s National Medical Center)

  • Timothy R. Hammond

    (Center for Neuroscience Research, Children’s National Medical Center
    Institute for Biomedical Sciences, The George Washington University)

  • Susanna Scafidi

    (Johns Hopkins University School of Medicine)

  • Jonathan Ritter

    (Center for Neuroscience Research, Children’s National Medical Center)

  • Beata Jablonska

    (Center for Neuroscience Research, Children’s National Medical Center)

  • Maria Roncal

    (Center for Neuroscience Research, Children’s National Medical Center)

  • Klara Szigeti-Buck

    (Yale University)

  • Daniel Coman

    (MRRC, Yale University)

  • Yuegao Huang

    (MRRC, Yale University)

  • Robert J. McCarter

    (Center for Translational Science, Children’s National Medical Center, Washington DC 20010, USA)

  • Fahmeed Hyder

    (MRRC, Yale University)

  • Tamas L. Horvath

    (Yale University)

  • Vittorio Gallo

    (Center for Neuroscience Research, Children’s National Medical Center)

Abstract

Diffuse white matter injury is common in very preterm infants; here, enhanced epidermal growth factor receptor signalling in oligodendrocyte precursor cells in a mouse model of such injury is shown to increase cellular and functional recovery.

Suggested Citation

  • Joseph Scafidi & Timothy R. Hammond & Susanna Scafidi & Jonathan Ritter & Beata Jablonska & Maria Roncal & Klara Szigeti-Buck & Daniel Coman & Yuegao Huang & Robert J. McCarter & Fahmeed Hyder & Tamas, 2014. "Intranasal epidermal growth factor treatment rescues neonatal brain injury," Nature, Nature, vol. 506(7487), pages 230-234, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7487:d:10.1038_nature12880
    DOI: 10.1038/nature12880
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