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Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA

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  • Lijun Zhou

    (Ministry of Education Key Laboratory of Protein Science, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Jing Hang

    (Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University)

  • Yulin Zhou

    (Ministry of Education Key Laboratory of Protein Science, Tsinghua University)

  • Ruixue Wan

    (State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University)

  • Guifeng Lu

    (State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University)

  • Ping Yin

    (Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

  • Chuangye Yan

    (Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University
    State Key Laboratory of Bio-membrane and Membrane Biotechnology, Tsinghua University)

  • Yigong Shi

    (Ministry of Education Key Laboratory of Protein Science, Tsinghua University
    Tsinghua-Peking Joint Center for Life Sciences, Center for Structural Biology, School of Life Sciences and School of Medicine, Tsinghua University)

Abstract

The crystal structure of the Lsm protein ring of the U6 small nuclear ribonucleoprotein (snRNP), with and without an RNA comprising the 3′ end of the U6 small nuclear RNA, is solved here; this structure provides insight into the function of U6 snRNP in precursor messenger RNA splicing.

Suggested Citation

  • Lijun Zhou & Jing Hang & Yulin Zhou & Ruixue Wan & Guifeng Lu & Ping Yin & Chuangye Yan & Yigong Shi, 2014. "Crystal structures of the Lsm complex bound to the 3′ end sequence of U6 small nuclear RNA," Nature, Nature, vol. 506(7486), pages 116-120, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7486:d:10.1038_nature12803
    DOI: 10.1038/nature12803
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    Cited by:

    1. Chi-Wei Yeh & Kuan-Lun Hsu & Shu-Ting Lin & Wei-Chieh Huang & Kun-Hai Yeh & Chien-Fu Jeff Liu & Li-Chin Wang & Ting-Ting Li & Shu-Chuan Chen & Chen-Hsin Yu & Jun-Yi Leu & Chen-Hsiang Yeang & Hsueh-Chi, 2024. "Altered assembly paths mitigate interference among paralogous complexes," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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