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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

Author

Listed:
  • John W. Schoggins

    (Laboratory of Virology and Infectious Disease, The Rockefeller University
    Present addresses: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA (J.W.S.); MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland G61 1QH, UK (R.M.E.).)

  • Donna A. MacDuff

    (Washington University School of Medicine)

  • Naoko Imanaka

    (Laboratory of Virology and Infectious Disease, The Rockefeller University)

  • Maria D. Gainey

    (and Howard Hughes Medical Institute, Washington University School of Medicine)

  • Bimmi Shrestha

    (Washington University School of Medicine)

  • Jennifer L. Eitson

    (University of Texas Southwestern Medical Center)

  • Katrina B. Mar

    (University of Texas Southwestern Medical Center)

  • R. Blake Richardson

    (University of Texas Southwestern Medical Center)

  • Alexander V. Ratushny

    (Seattle Biomedical Research Institute
    Institute for Systems Biology)

  • Vladimir Litvak

    (Seattle Biomedical Research Institute)

  • Rea Dabelic

    (Columbia University)

  • Balaji Manicassamy

    (University of Chicago)

  • John D. Aitchison

    (Seattle Biomedical Research Institute
    Institute for Systems Biology)

  • Alan Aderem

    (Seattle Biomedical Research Institute)

  • Richard M. Elliott

    (School of Biology, University of St Andrews, St Andrews, Scotland KY16 9ST, UK
    Present addresses: Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA (J.W.S.); MRC-University of Glasgow Centre for Virus Research, Glasgow, Scotland G61 1QH, UK (R.M.E.).)

  • Adolfo García-Sastre

    (Icahn School of Medicine at Mount Sinai
    Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Vincent Racaniello

    (Columbia University)

  • Eric J. Snijder

    (Leiden University Medical Center, Leiden 2300 RC, The Netherlands)

  • Wayne M. Yokoyama

    (and Howard Hughes Medical Institute, Washington University School of Medicine)

  • Michael S. Diamond

    (Washington University School of Medicine
    Washington University School of Medicine)

  • Herbert W. Virgin

    (Washington University School of Medicine)

  • Charles M. Rice

    (Laboratory of Virology and Infectious Disease, The Rockefeller University)

Abstract

The specificity of interferon effectors across an expanded range of viruses is studied, with results indicating that positive-sense single-stranded RNA viruses are more susceptible to interferon-stimulated gene activity than negative-sense RNA or DNA viruses; in addition, the DNA sensor cGAS is shown to have an unappreciated role in RNA virus inhibition.

Suggested Citation

  • John W. Schoggins & Donna A. MacDuff & Naoko Imanaka & Maria D. Gainey & Bimmi Shrestha & Jennifer L. Eitson & Katrina B. Mar & R. Blake Richardson & Alexander V. Ratushny & Vladimir Litvak & Rea Dabe, 2014. "Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity," Nature, Nature, vol. 505(7485), pages 691-695, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7485:d:10.1038_nature12862
    DOI: 10.1038/nature12862
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