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Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

Author

Listed:
  • Daisuke Nakada

    (Baylor College of Medicine
    Stem Cells and Regenerative Medicine Center, Baylor College of Medicine
    Center for Cell and Gene Therapy, Baylor College of Medicine)

  • Hideyuki Oguro

    (Howard Hughes Medical Institute, and Children’s Research Institute, University of Texas Southwestern Medical Center)

  • Boaz P. Levi

    (Life Sciences Institute, Center for Stem Cell Biology, University of Michigan)

  • Nicole Ryan

    (Baylor College of Medicine)

  • Ayumi Kitano

    (Baylor College of Medicine)

  • Yusuke Saitoh

    (Baylor College of Medicine)

  • Makiko Takeichi

    (Baylor College of Medicine)

  • George R. Wendt

    (Life Sciences Institute, Center for Stem Cell Biology, University of Michigan)

  • Sean J. Morrison

    (Howard Hughes Medical Institute, and Children’s Research Institute, University of Texas Southwestern Medical Center)

Abstract

Haematopoietic stem cells are found to be regulated differently in male and female mice — haematopoietic stem cells in females divide more frequently than in males in response to oestrogen and this difference depends on the ovaries but not the testes; using a genetic approach, it is shown that the effect is dependent on expression of oestrogen receptor-α (ERα) in stem cells.

Suggested Citation

  • Daisuke Nakada & Hideyuki Oguro & Boaz P. Levi & Nicole Ryan & Ayumi Kitano & Yusuke Saitoh & Makiko Takeichi & George R. Wendt & Sean J. Morrison, 2014. "Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy," Nature, Nature, vol. 505(7484), pages 555-558, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7484:d:10.1038_nature12932
    DOI: 10.1038/nature12932
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    Cited by:

    1. Yu-Jung Tseng & Yuki Kageyama & Rebecca L. Murdaugh & Ayumi Kitano & Jong Hwan Kim & Kevin A. Hoegenauer & Jonathan Tiessen & Mackenzie H. Smith & Hidetaka Uryu & Koichi Takahashi & James F. Martin & , 2024. "Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Tom W. Andrew & Lauren S. Koepke & Yuting Wang & Michael Lopez & Holly Steininger & Danielle Struck & Tatiana Boyko & Thomas H. Ambrosi & Xinming Tong & Yuxi Sun & Gunsagar S. Gulati & Matthew P. Murp, 2022. "Sexually dimorphic estrogen sensing in skeletal stem cells controls skeletal regeneration," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    3. Kiyoka Saito & Mark Garde & Terumasa Umemoto & Natsumi Miharada & Julia Sjöberg & Valgardur Sigurdsson & Haruki Shirozu & Shunsuke Kamei & Visnja Radulovic & Mitsuyoshi Suzuki & Satoshi Nakano & Stefa, 2024. "Lipoprotein metabolism mediates hematopoietic stem cell responses under acute anemic conditions," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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