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Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

Author

Listed:
  • Chi Nguyen

    (Chemistry, and Pharmaceutical Sciences, University of California)

  • Robert W. Haushalter

    (University of California, San Diego, La Jolla, California 92093, USA)

  • D. John Lee

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Phineus R. L. Markwick

    (University of California, San Diego, La Jolla, California 92093, USA
    San Diego Supercomputer Center
    Howard Hughes Medical Institute)

  • Joel Bruegger

    (Chemistry, and Pharmaceutical Sciences, University of California)

  • Grace Caldara-Festin

    (Chemistry, and Pharmaceutical Sciences, University of California)

  • Kara Finzel

    (University of California, San Diego, La Jolla, California 92093, USA)

  • David R. Jackson

    (Chemistry, and Pharmaceutical Sciences, University of California)

  • Fumihiro Ishikawa

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Bing O’Dowd

    (University of California, San Diego, La Jolla, California 92093, USA)

  • J. Andrew McCammon

    (University of California, San Diego, La Jolla, California 92093, USA
    Howard Hughes Medical Institute)

  • Stanley J. Opella

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Shiou-Chuan Tsai

    (Chemistry, and Pharmaceutical Sciences, University of California)

  • Michael D. Burkart

    (University of California, San Diego, La Jolla, California 92093, USA)

Abstract

A highly specific chemical crosslinking method is used to trap a complex between an acyl carrier protein and a fatty acid dehydratase during fatty acid biosynthesis; subsequent X-ray crystallography, NMR spectroscopy and molecular dynamics simulations techniques enable the detailed study of this complex.

Suggested Citation

  • Chi Nguyen & Robert W. Haushalter & D. John Lee & Phineus R. L. Markwick & Joel Bruegger & Grace Caldara-Festin & Kara Finzel & David R. Jackson & Fumihiro Ishikawa & Bing O’Dowd & J. Andrew McCammon , 2014. "Trapping the dynamic acyl carrier protein in fatty acid biosynthesis," Nature, Nature, vol. 505(7483), pages 427-431, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7483:d:10.1038_nature12810
    DOI: 10.1038/nature12810
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    Cited by:

    1. Qian Wang & Ning Liu & Yaming Deng & Yuze Guan & Hongli Xiao & Tara A. Nitka & Hui Yang & Anju Yadav & Lela Vukovic & Irimpan I. Mathews & Xi Chen & Chu-Young Kim, 2023. "Triepoxide formation by a flavin-dependent monooxygenase in monensin biosynthesis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Josh P. Prince & Jani R. Bolla & Gemma L. M. Fisher & Jarno Mäkelä & Marjorie Fournier & Carol V. Robinson & Lidia K. Arciszewska & David J. Sherratt, 2021. "Acyl carrier protein promotes MukBEF action in Escherichia coli chromosome organization-segregation," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    3. Christopher J. Barden & Fan Wu & J. Pedro Fernandez-Murray & Erhu Lu & Shengguo Sun & Marcia M. Taylor & Annette L. Rushton & Jason Williams & Mahtab Tavasoli & Autumn Meek & Alla Siva Reddy & Lisa M., 2024. "Computer-aided drug design to generate a unique antibiotic family," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Jiashen Zhou & Lin Zhang & Liping Zeng & Lu Yu & Yuanyuan Duan & Siqi Shen & Jingyan Hu & Pan Zhang & Wenyan Song & Xiaoxue Ruan & Jing Jiang & Yinan Zhang & Lu Zhou & Jia Jia & Xudong Hang & Changlin, 2021. "Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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