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Muc5b is required for airway defence

Author

Listed:
  • Michelle G. Roy

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Alessandra Livraghi-Butrico

    (University of North Carolina-Chapel Hill, 7011 Thurston-Bowles Building, Chapel Hill, North Carolina 27599, USA)

  • Ashley A. Fletcher

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Melissa M. McElwee

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Scott E. Evans

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Ryan M. Boerner

    (University of Texas Health Science Center-Houston Medical School, 6431 Fannin Street)

  • Samantha N. Alexander

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Lindsey K. Bellinghausen

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Alfred S. Song

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Youlia M. Petrova

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Michael J. Tuvim

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Roberto Adachi

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Irlanda Romo

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Instituto Tecnológico y de Estudios Superiores de Monterrey, Avenida Eugenio Garza Sada 2501 Sur Colonia Tecnológico, Monterrey, Nuevo León 64849, Mexico)

  • Andrea S. Bordt

    (Texas A&M Health Science Center, 2121 W. Holcombe Boulevard)

  • M. Gabriela Bowden

    (Texas A&M Health Science Center, 2121 W. Holcombe Boulevard
    University of Houston-Downtown, 1 Main Street)

  • Joseph H. Sisson

    (University of Nebraska Medical Center, 985910 Nebraska Medical Center)

  • Prescott G. Woodruff

    (University of California San Francisco, 505 Parnassus Avenue)

  • David J. Thornton

    (University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK)

  • Karine Rousseau

    (University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK)

  • Maria M. De la Garza

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Seyed J. Moghaddam

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Harry Karmouty-Quintana

    (University of Texas Health Science Center-Houston Medical School, 6431 Fannin Street)

  • Michael R. Blackburn

    (University of Texas Health Science Center-Houston Medical School, 6431 Fannin Street)

  • Scott M. Drouin

    (University of Texas Health Science Center-Houston Medical School, 6431 Fannin Street)

  • C. William Davis

    (University of North Carolina-Chapel Hill, 7011 Thurston-Bowles Building, Chapel Hill, North Carolina 27599, USA)

  • Kristy A. Terrell

    (University of North Carolina-Chapel Hill, 7011 Thurston-Bowles Building, Chapel Hill, North Carolina 27599, USA)

  • Barbara R. Grubb

    (University of North Carolina-Chapel Hill, 7011 Thurston-Bowles Building, Chapel Hill, North Carolina 27599, USA)

  • Wanda K. O’Neal

    (University of North Carolina-Chapel Hill, 7011 Thurston-Bowles Building, Chapel Hill, North Carolina 27599, USA)

  • Sonia C. Flores

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Adela Cota-Gomez

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Catherine A. Lozupone

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Jody M. Donnelly

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Alan M. Watson

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Corinne E. Hennessy

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Rebecca C. Keith

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Ivana V. Yang

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Lea Barthel

    (University of Colorado School of Medicine, 12700 East 19th Avenue
    National Jewish Health)

  • Peter M. Henson

    (University of Colorado School of Medicine, 12700 East 19th Avenue
    National Jewish Health)

  • William J. Janssen

    (University of Colorado School of Medicine, 12700 East 19th Avenue
    National Jewish Health)

  • David A. Schwartz

    (University of Colorado School of Medicine, 12700 East 19th Avenue)

  • Richard C. Boucher

    (University of North Carolina-Chapel Hill, 7011 Thurston-Bowles Building, Chapel Hill, North Carolina 27599, USA)

  • Burton F. Dickey

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA)

  • Christopher M. Evans

    (University of Texas, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    University of Colorado School of Medicine, 12700 East 19th Avenue)

Abstract

The airway mucin Muc5b (but not Muc5ac) is required for mucociliary clearance, defence against bacterial infection in the airways and middle ear, and maintenance of immune homeostasis in the lungs; Muc5b deficiency causes accumulation of apoptotic macrophages, impairment of phagocytosis and reduced production of interleukin-23, leading to infection and inflammation.

Suggested Citation

  • Michelle G. Roy & Alessandra Livraghi-Butrico & Ashley A. Fletcher & Melissa M. McElwee & Scott E. Evans & Ryan M. Boerner & Samantha N. Alexander & Lindsey K. Bellinghausen & Alfred S. Song & Youlia , 2014. "Muc5b is required for airway defence," Nature, Nature, vol. 505(7483), pages 412-416, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7483:d:10.1038_nature12807
    DOI: 10.1038/nature12807
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    Citations

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    Cited by:

    1. Joschka Hey & Michelle Paulsen & Reka Toth & Dieter Weichenhan & Simone Butz & Jolanthe Schatterny & Reinhard Liebers & Pavlo Lutsik & Christoph Plass & Marcus A. Mall, 2021. "Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    2. Maria J. Garcia-Leon & Cristina Liboni & Vincent Mittelheisser & Louis Bochler & Gautier Follain & Clarisse Mouriaux & Ignacio Busnelli & Annabel Larnicol & Florent Colin & Marina Peralta & Naël Osman, 2024. "Platelets favor the outgrowth of established metastases," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    3. Robert M. Cox & Josef D. Wolf & Nicole A. Lieberman & Carolin M. Lieber & Hae-Ji Kang & Zachary M. Sticher & Jeong-Joong Yoon & Meghan K. Andrews & Mugunthan Govindarajan & Rebecca E. Krueger & Elizab, 2024. "Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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