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Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif

Author

Listed:
  • Yingying Guo

    (School of Life Science and Technology, Harbin Institute of Technology)

  • Liyong Dong

    (School of Life Science and Technology, Harbin Institute of Technology)

  • Xiaolin Qiu

    (School of Life Science and Technology, Harbin Institute of Technology)

  • Yishu Wang

    (School of Life Science and Technology, Harbin Institute of Technology)

  • Bailing Zhang

    (School of Life Science and Technology, Harbin Institute of Technology)

  • Hongnan Liu

    (School of Life Science and Technology, Harbin Institute of Technology)

  • You Yu

    (MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

  • Yi Zang

    (School of Life Science and Technology, Harbin Institute of Technology)

  • Maojun Yang

    (MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University)

  • Zhiwei Huang

    (School of Life Science and Technology, Harbin Institute of Technology)

Abstract

This study provides a crystal structure of the Vif–CBF-β–CUL5–ELOB–ELOC complex, which shows that Vif mimics the action of SOCS2 to interact with CUL5 and ELOC.

Suggested Citation

  • Yingying Guo & Liyong Dong & Xiaolin Qiu & Yishu Wang & Bailing Zhang & Hongnan Liu & You Yu & Yi Zang & Maojun Yang & Zhiwei Huang, 2014. "Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif," Nature, Nature, vol. 505(7482), pages 229-233, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7482:d:10.1038_nature12884
    DOI: 10.1038/nature12884
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