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Structural basis of lentiviral subversion of a cellular protein degradation pathway

Author

Listed:
  • David Schwefel

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Harriet C. T. Groom

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Virginie C. Boucherit

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Evangelos Christodoulou

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Philip A. Walker

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Jonathan P. Stoye

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Kate N. Bishop

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

  • Ian A. Taylor

    (MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK)

Abstract

The crystal structure of a ternary complex of the lentiviral accessory protein Vpx with the E3 ligase substrate adaptor DCAF1 and the HIV-1 restriction factor SAMHD1 shows how Vpx recruits SAMHD1 to the cell’s ubiquitination machinery.

Suggested Citation

  • David Schwefel & Harriet C. T. Groom & Virginie C. Boucherit & Evangelos Christodoulou & Philip A. Walker & Jonathan P. Stoye & Kate N. Bishop & Ian A. Taylor, 2014. "Structural basis of lentiviral subversion of a cellular protein degradation pathway," Nature, Nature, vol. 505(7482), pages 234-238, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7482:d:10.1038_nature12815
    DOI: 10.1038/nature12815
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    Cited by:

    1. Oliver J. Acton & Devon Sheppard & Simone Kunzelmann & Sarah J. Caswell & Andrea Nans & Ailidh J. O. Burgess & Geoff Kelly & Elizabeth R. Morris & Peter B. Rosenthal & Ian A. Taylor, 2024. "Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Jung-Eun Park & Tae-Sung Kim & Yan Zeng & Melissa Mikolaj & Jong Ahn & Muhammad S. Alam & Christina M. Monnie & Victoria Shi & Ming Zhou & Tae-Wook Chun & Frank Maldarelli & Kedar Narayan & Jinwoo Ahn, 2024. "Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Martin Schröder & Martin Renatus & Xiaoyou Liang & Fabian Meili & Thomas Zoller & Sandrine Ferrand & Francois Gauter & Xiaoyan Li & Frederic Sigoillot & Scott Gleim & Therese-Marie Stachyra & Jason R., 2024. "DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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