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Transcranial amelioration of inflammation and cell death after brain injury

Author

Listed:
  • Theodore L. Roth

    (National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Debasis Nayak

    (National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Tatjana Atanasijevic

    (National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Alan P. Koretsky

    (National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Lawrence L. Latour

    (National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Dorian B. McGavern

    (National Institute of Neurological Disorders and Stroke, National Institutes of Health)

Abstract

Using long-term intravital photography to explore the cellular changes after compression-induced traumatic brain injury in a murine model, it is shown that parenchymal and meningeal inflammation as well as cell death can be modulated by topical treatment with purinergic receptor antagonists and glutathione.

Suggested Citation

  • Theodore L. Roth & Debasis Nayak & Tatjana Atanasijevic & Alan P. Koretsky & Lawrence L. Latour & Dorian B. McGavern, 2014. "Transcranial amelioration of inflammation and cell death after brain injury," Nature, Nature, vol. 505(7482), pages 223-228, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7482:d:10.1038_nature12808
    DOI: 10.1038/nature12808
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    Cited by:

    1. Ming Xu & Min Xu & Lei Han & Chao Yuan & Yong Mei & Hengdong Zhang & Shi Chen & Kai Sun & Baoli Zhu, 2017. "Role for Functional SOD2 Polymorphism in Pulmonary Arterial Hypertension in a Chinese Population," IJERPH, MDPI, vol. 14(3), pages 1-8, March.

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