IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v505y2014i7482d10.1038_nature12785.html
   My bibliography  Save this article

HMGA2 functions as a competing endogenous RNA to promote lung cancer progression

Author

Listed:
  • Madhu S. Kumar

    (Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Elena Armenteros-Monterroso

    (Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Philip East

    (Bioinformatics and Biostatistics Group, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Probir Chakravorty

    (Bioinformatics and Biostatistics Group, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Nik Matthews

    (Advanced Sequencing Facility, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Monte M. Winslow

    (the Stanford Cancer Institute, Stanford University School of Medicine)

  • Julian Downward

    (Signal Transduction Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK
    Lung Cancer Group, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

Abstract

HMGA2 promotes lung cancer progression in mice and humans; in mouse and human lung cancer cells, HMGA2 competes with mRNAs like TGFBR3 for the let-7 microRNA family, and in human non-small-cell lung cancer tissue, expression levels of HMGA2 and TGFBR3 are correlated, suggesting that HMGA2 functions both as a protein-coding gene and as a non-coding RNA.

Suggested Citation

  • Madhu S. Kumar & Elena Armenteros-Monterroso & Philip East & Probir Chakravorty & Nik Matthews & Monte M. Winslow & Julian Downward, 2014. "HMGA2 functions as a competing endogenous RNA to promote lung cancer progression," Nature, Nature, vol. 505(7482), pages 212-217, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7482:d:10.1038_nature12785
    DOI: 10.1038/nature12785
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12785
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12785?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:505:y:2014:i:7482:d:10.1038_nature12785. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.