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De novo protein crystal structure determination from X-ray free-electron laser data

Author

Listed:
  • Thomas R. M. Barends

    (Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany)

  • Lutz Foucar

    (Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany)

  • Sabine Botha

    (Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany)

  • R. Bruce Doak

    (Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany
    Arizona State University, PO Box 871504, Tempe, Arizona 85287-1504, USA)

  • Robert L. Shoeman

    (Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany)

  • Karol Nass

    (Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany)

  • Jason E. Koglin

    (SLAC National Accelerator Laboratory, 2575 Sand Hill Road)

  • Garth J. Williams

    (SLAC National Accelerator Laboratory, 2575 Sand Hill Road)

  • Sébastien Boutet

    (SLAC National Accelerator Laboratory, 2575 Sand Hill Road)

  • Marc Messerschmidt

    (SLAC National Accelerator Laboratory, 2575 Sand Hill Road)

  • Ilme Schlichting

    (Max-Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany)

Abstract

Femtosecond crystallography with an X-ray free-electron laser is used to analyse micrometre-sized protein crystals, generating a high-resolution structure of the protein without previous knowledge of what it looks like.

Suggested Citation

  • Thomas R. M. Barends & Lutz Foucar & Sabine Botha & R. Bruce Doak & Robert L. Shoeman & Karol Nass & Jason E. Koglin & Garth J. Williams & Sébastien Boutet & Marc Messerschmidt & Ilme Schlichting, 2014. "De novo protein crystal structure determination from X-ray free-electron laser data," Nature, Nature, vol. 505(7482), pages 244-247, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7482:d:10.1038_nature12773
    DOI: 10.1038/nature12773
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    Cited by:

    1. Maximilian Wranik & Michal W. Kepa & Emma V. Beale & Daniel James & Quentin Bertrand & Tobias Weinert & Antonia Furrer & Hannah Glover & Dardan Gashi & Melissa Carrillo & Yasushi Kondo & Robin T. Stip, 2023. "A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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