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The effects of genetic variation on gene expression dynamics during development

Author

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  • Mirko Francesconi

    (EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain
    Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain)

  • Ben Lehner

    (EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003 Barcelona, Spain
    Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003 Barcelona, Spain
    Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain)

Abstract

A comprehensive study into the effects of polymorphisms on gene expression dynamics during a 12-hour development period of Caenorhabditis elegans shows that both cis and trans expression quantitative trait loci (eQTLs) can increase and decrease gene expression, depending on the time point, and that trans eQTLs can act as modifiers of expression during a given period of development.

Suggested Citation

  • Mirko Francesconi & Ben Lehner, 2014. "The effects of genetic variation on gene expression dynamics during development," Nature, Nature, vol. 505(7482), pages 208-211, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7482:d:10.1038_nature12772
    DOI: 10.1038/nature12772
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    Cited by:

    1. Jasper Panten & Tobias Heinen & Christina Ernst & Nils Eling & Rebecca E. Wagner & Maja Satorius & John C. Marioni & Oliver Stegle & Duncan T. Odom, 2024. "The dynamic genetic determinants of increased transcriptional divergence in spermatids," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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