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Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression

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  • Julien Courtin

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

  • Fabrice Chaudun

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

  • Robert R. Rozeske

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

  • Nikolaos Karalis

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

  • Cecilia Gonzalez-Campo

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

  • Hélène Wurtz

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

  • Azzedine Abdi

    (University of Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France
    CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France)

  • Jerome Baufreton

    (University of Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France
    CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux F-33000, France)

  • Thomas C. M. Bienvenu

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

  • Cyril Herry

    (INSERM, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France
    University of Bordeaux, Neurocentre Magendie, U862, 146 Rue Léo-Saignat, Bordeaux 33077, France)

Abstract

Single-unit recordings and optogenetic manipulations in mice undergoing auditory fear conditioning show that fear expression is related to the phasic inhibition of prefrontal cortex (PFC) parvalbumin interneurons; inhibition disinhibits PFC projection neurons and synchronizes their firing, leading to fear expression.

Suggested Citation

  • Julien Courtin & Fabrice Chaudun & Robert R. Rozeske & Nikolaos Karalis & Cecilia Gonzalez-Campo & Hélène Wurtz & Azzedine Abdi & Jerome Baufreton & Thomas C. M. Bienvenu & Cyril Herry, 2014. "Prefrontal parvalbumin interneurons shape neuronal activity to drive fear expression," Nature, Nature, vol. 505(7481), pages 92-96, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7481:d:10.1038_nature12755
    DOI: 10.1038/nature12755
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    Cited by:

    1. Masakazu Agetsuma & Issei Sato & Yasuhiro R. Tanaka & Luis Carrillo-Reid & Atsushi Kasai & Atsushi Noritake & Yoshiyuki Arai & Miki Yoshitomo & Takashi Inagaki & Hiroshi Yukawa & Hitoshi Hashimoto & J, 2023. "Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    2. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. David Eriksson & Artur Schneider & Anupriya Thirumalai & Mansour Alyahyay & Brice Crompe & Kirti Sharma & Patrick Ruther & Ilka Diester, 2022. "Multichannel optogenetics combined with laminar recordings for ultra-controlled neuronal interrogation," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    4. Jun Ma & John J. O’Malley & Malaz Kreiker & Yan Leng & Isbah Khan & Morgan Kindel & Mario A. Penzo, 2024. "Convergent direct and indirect cortical streams shape avoidance decisions in mice via the midline thalamus," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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