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N6-methyladenosine-dependent regulation of messenger RNA stability

Author

Listed:
  • Xiao Wang

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Zhike Lu

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Adrian Gomez

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Gary C. Hon

    (Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA)

  • Yanan Yue

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Dali Han

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Ye Fu

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Marc Parisien

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Qing Dai

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Guifang Jia

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    College of Chemistry and Molecular Engineering, Peking University)

  • Bing Ren

    (Ludwig Institute for Cancer Research, UCSD Moores Cancer Center and Institute of Genome Medicine, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0653, USA)

  • Tao Pan

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

  • Chuan He

    (The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA)

Abstract

The mRNAs of higher eukaryotes are extensively modified internally with N6-methyladenosine, but the specific functional role of this modification has been unclear; here this modification on mRNA is shown to be recognized by several proteins, the modification and its recognition serve to regulate the RNA’s lifetime.

Suggested Citation

  • Xiao Wang & Zhike Lu & Adrian Gomez & Gary C. Hon & Yanan Yue & Dali Han & Ye Fu & Marc Parisien & Qing Dai & Guifang Jia & Bing Ren & Tao Pan & Chuan He, 2014. "N6-methyladenosine-dependent regulation of messenger RNA stability," Nature, Nature, vol. 505(7481), pages 117-120, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7481:d:10.1038_nature12730
    DOI: 10.1038/nature12730
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