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Antibacterial membrane attack by a pore-forming intestinal C-type lectin

Author

Listed:
  • Sohini Mukherjee

    (The University of Texas Southwestern Medical Center)

  • Hui Zheng

    (The University of Texas Southwestern Medical Center)

  • Mehabaw G. Derebe

    (The University of Texas Southwestern Medical Center)

  • Keith M. Callenberg

    (University of Pittsburgh, and Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology)

  • Carrie L. Partch

    (University of California)

  • Darcy Rollins

    (The University of Texas Southwestern Medical Center)

  • Daniel C. Propheter

    (The University of Texas Southwestern Medical Center)

  • Josep Rizo

    (The University of Texas Southwestern Medical Center)

  • Michael Grabe

    (University of Pittsburgh, and Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology
    Present address: Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, USA.)

  • Qiu-Xing Jiang

    (The University of Texas Southwestern Medical Center)

  • Lora V. Hooper

    (The University of Texas Southwestern Medical Center
    The Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center)

Abstract

Secreted C-type lectins protect the intestinal epithelium from Gram-positive bacteria; this study shows that for the C-type lectin RegIIIα, bacterial killing occurs in a two-step process whereby the lectin first binds to bacterial peptidoglycans then oligomerizes on the bacterial membrane to form a permeabilizing pore.

Suggested Citation

  • Sohini Mukherjee & Hui Zheng & Mehabaw G. Derebe & Keith M. Callenberg & Carrie L. Partch & Darcy Rollins & Daniel C. Propheter & Josep Rizo & Michael Grabe & Qiu-Xing Jiang & Lora V. Hooper, 2014. "Antibacterial membrane attack by a pore-forming intestinal C-type lectin," Nature, Nature, vol. 505(7481), pages 103-107, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7481:d:10.1038_nature12729
    DOI: 10.1038/nature12729
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