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Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

Author

Listed:
  • Bi-Sen Ding

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College)

  • Zhongwei Cao

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College)

  • Raphael Lis

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College)

  • Daniel J. Nolan

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College
    Angiocrine Bioscience)

  • Peipei Guo

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College)

  • Michael Simons

    (Yale Cardiovascular Research Center, Yale University School of Medicine)

  • Mark E. Penfold

    (ChemoCentryx, Inc.)

  • Koji Shido

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College)

  • Sina Y. Rabbany

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College
    Bioengineering Program, Hofstra University)

  • Shahin Rafii

    (Ansary Stem Cell Institute, Howard Hughes Medical Institute, Weill Cornell Medical College)

Abstract

Divergent angiocrine signals from liver sinusoidal endothelial cells elicit regeneration after immediate injury and provoke fibrosis after chronic insult.

Suggested Citation

  • Bi-Sen Ding & Zhongwei Cao & Raphael Lis & Daniel J. Nolan & Peipei Guo & Michael Simons & Mark E. Penfold & Koji Shido & Sina Y. Rabbany & Shahin Rafii, 2014. "Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis," Nature, Nature, vol. 505(7481), pages 97-102, January.
    • Handle: RePEc:nat:nature:v:505:y:2014:i:7481:d:10.1038_nature12681
    DOI: 10.1038/nature12681
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    Cited by:

    1. Linda Große-Segerath & Paula Follert & Kristina Behnke & Julia Ettich & Tobias Buschmann & Philip Kirschner & Sonja Hartwig & Stefan Lehr & Mortimer Korf-Klingebiel & Daniel Eberhard & Nadja Lehwald-T, 2024. "Identification of myeloid-derived growth factor as a mechanically-induced, growth-promoting angiocrine signal for human hepatocytes," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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