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The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality

Author

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  • Marko T. Boskovski

    (Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Present address: Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA.)

  • Shiaulou Yuan

    (Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Nis Borbye Pedersen

    (Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, Building 24.6.30, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark)

  • Christoffer Knak Goth

    (Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, Building 24.6.30, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark)

  • Svetlana Makova

    (Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Henrik Clausen

    (Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, Building 24.6.30, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark)

  • Martina Brueckner

    (Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Mustafa K. Khokha

    (Program in Vertebrate Developmental Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

Abstract

The O-glycosylation enzyme Galnt11 has an important role in heterotaxy, a disorder of left–right body patterning or laterality: Galnt11 modulates Notch signalling which alters cilia types at the embryonic left–right organizer, therefore determining laterality.

Suggested Citation

  • Marko T. Boskovski & Shiaulou Yuan & Nis Borbye Pedersen & Christoffer Knak Goth & Svetlana Makova & Henrik Clausen & Martina Brueckner & Mustafa K. Khokha, 2013. "The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality," Nature, Nature, vol. 504(7480), pages 456-459, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12723
    DOI: 10.1038/nature12723
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    Cited by:

    1. Shengjun Wang & Wei Ran & Lingyu Sun & Qingchi Fan & Yuanqi Zhao & Bowen Wang & Jinghong Yang & Yuqi He & Ying Wu & Yuanyuan Wang & Luoyi Chen & Arpaporn Chuchuay & Yuyu You & Xinhai Zhu & Xiaojuan Wa, 2024. "Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Daniel Madriz Sørensen & Christian Büll & Thomas D. Madsen & Erandi Lira-Navarrete & Thomas Mandel Clausen & Alex E. Clark & Aaron F. Garretson & Richard Karlsson & Johan F. A. Pijnenborg & Xin Yin & , 2023. "Identification of global inhibitors of cellular glycosylation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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