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Dysfunctional nitric oxide signalling increases risk of myocardial infarction

Author

Listed:
  • Jeanette Erdmann

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany
    German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany)

  • Klaus Stark

    (Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, 93053 Regensburg, Germany
    University of Regensburg, 93053 Regensburg, Germany)

  • Ulrike B. Esslinger

    (Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, 93053 Regensburg, Germany
    Institut National de la Santé et de la Recherche Médicale (INSERM), UMR-S937 Paris, France)

  • Philipp Moritz Rumpf

    (Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 80636 München, Germany
    German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, 80636 Munich, Germany)

  • Doris Koesling

    (Ruhr-University Bochum, 44801 Bochum, Germany)

  • Cor de Wit

    (German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany
    Institut für Physiologie, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Frank J. Kaiser

    (German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany
    Institut für Humangenetik, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Diana Braunholz

    (Institut für Humangenetik, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Anja Medack

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Marcus Fischer

    (Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, 93053 Regensburg, Germany)

  • Martina E. Zimmermann

    (Klinik und Poliklinik für Innere Medizin II, Universitätsklinikum Regensburg, 93053 Regensburg, Germany)

  • Stephanie Tennstedt

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Elisabeth Graf

    (Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Institute of Human Genetics, Technische Universität München, 81675 München, Germany)

  • Sebastian Eck

    (Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Institute of Human Genetics, Technische Universität München, 81675 München, Germany)

  • Zouhair Aherrahrou

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany
    German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany)

  • Janja Nahrstaedt

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Christina Willenborg

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany
    German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Lübeck/Kiel, 23562 Lübeck, Germany)

  • Petra Bruse

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Ingrid Brænne

    (Institut für Integrative und Experimentelle Genomik, Universität zu Lübeck, 23562 Lübeck, Germany)

  • Markus M. Nöthen

    (Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany
    Research Center Life & Brain, University of Bonn, 53127 Bonn, Germany)

  • Per Hofmann

    (Institute of Human Genetics, University of Bonn, 53127 Bonn, Germany
    University of Basel, 4003 Basel, Switzerland)

  • Peter S. Braund

    (University of Leicester, Leicester LE1 7RH, UK
    Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE1 7RH, UK)

  • Evanthia Mergia

    (Ruhr-University Bochum, 44801 Bochum, Germany)

  • Wibke Reinhard

    (Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 80636 München, Germany
    German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, 80636 Munich, Germany)

  • Christof Burgdorf

    (Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 80636 München, Germany)

  • Stefan Schreiber

    (Institute of Clinical Molecular Biology, Christian-Albrecht-Universität, 24105 Kiel, Germany)

  • Anthony J. Balmforth

    (Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK)

  • Alistair S. Hall

    (Multidisciplinary Cardiovascular Research Centre, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK)

  • Lars Bertram

    (Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany)

  • Elisabeth Steinhagen-Thiessen

    (Charité Research Group on Geriatrics, Charité-Universitätsmedizin, 10117 Berlin, Germany)

  • Shu-Chen Li

    (Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany
    TU Dresden, 01062 Dresden, Germany)

  • Winfried März

    (Synlab Academy and Business Development, synlab Services GmbH, 68165 Mannheim, Germany
    Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria
    Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, 68167 Mannheim, Germany)

  • Muredach Reilly

    (The Cardiovascular Institute, University of Pennsylvania)

  • Sekar Kathiresan

    (Massachusetts General Hospital
    Center for Human Genetic Research, Massachusetts General Hospital
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT))

  • Ruth McPherson

    (University of Ottawa, Heart Institute, Ottawa, Ontario K1Y 4W7, Canada)

  • Ulrich Walter

    (Centrum für Thrombose und Hämostase (CTH), Universitätsmedizin Mainz, 55131 Mainz, Germany
    German Centre for Cardiovascular Research (DZHK), partner site RheinMain, 55131 Mainz, Germany)

  • Jurg Ott

    (Institute of Psychology, Chinese Academy of Sciences
    Laboratory of Statistical Genetics, Rockefeller University)

  • Nilesh J. Samani

    (University of Leicester, Leicester LE1 7RH, UK
    Leicester National Institute for Health Research Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE1 7RH, UK)

  • Tim M. Strom

    (Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Institute of Human Genetics, Technische Universität München, 81675 München, Germany)

  • Thomas Meitinger

    (Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 80636 München, Germany
    Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Institute of Human Genetics, Technische Universität München, 81675 München, Germany)

  • Christian Hengstenberg

    (Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 80636 München, Germany
    German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, 80636 Munich, Germany)

  • Heribert Schunkert

    (Deutsches Herzzentrum München and 1. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 80636 München, Germany
    German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, 80636 Munich, Germany)

Abstract

Two private, heterozygous mutations in two functionally related genes, GUCY1A3 and CCT7, are identified in an extended family with myocardial infarction; these genes encode proteins that work together to inhibit platelet activation after nitric oxide stimulation, suggesting a link between impaired nitric oxide signalling and myocardial infarction risk.

Suggested Citation

  • Jeanette Erdmann & Klaus Stark & Ulrike B. Esslinger & Philipp Moritz Rumpf & Doris Koesling & Cor de Wit & Frank J. Kaiser & Diana Braunholz & Anja Medack & Marcus Fischer & Martina E. Zimmermann & S, 2013. "Dysfunctional nitric oxide signalling increases risk of myocardial infarction," Nature, Nature, vol. 504(7480), pages 432-436, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12722
    DOI: 10.1038/nature12722
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