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High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

Author

Listed:
  • Matthew D. Simon

    (Massachusetts General Hospital, Harvard Medical School
    and Chemical Biology Institute, Yale University)

  • Stefan F. Pinter

    (Massachusetts General Hospital, Harvard Medical School
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School)

  • Rui Fang

    (and Chemical Biology Institute, Yale University)

  • Kavitha Sarma

    (Massachusetts General Hospital, Harvard Medical School
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School)

  • Michael Rutenberg-Schoenberg

    (and Chemical Biology Institute, Yale University)

  • Sarah K. Bowman

    (Massachusetts General Hospital, Harvard Medical School)

  • Barry A. Kesner

    (Massachusetts General Hospital, Harvard Medical School
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School)

  • Verena K. Maier

    (Massachusetts General Hospital, Harvard Medical School
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School)

  • Robert E. Kingston

    (Massachusetts General Hospital, Harvard Medical School)

  • Jeannie T. Lee

    (Massachusetts General Hospital, Harvard Medical School
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School)

Abstract

During mammalian X-chromosome inactivation, the Xist long noncoding RNA coats the future inactive X chromosome and recruits polycomb repressive complex 2 to a nucleation site, but how Xist spreads silencing across the entire X chromosome is unclear; here high-resolution maps of Xist binding sites across the X chromosome are generated and show that Xist does not spread across the inactive X chromosome uniformly but in two steps, initially targeting gene-rich islands before later spreading to intervening gene-poor domains.

Suggested Citation

  • Matthew D. Simon & Stefan F. Pinter & Rui Fang & Kavitha Sarma & Michael Rutenberg-Schoenberg & Sarah K. Bowman & Barry A. Kesner & Verena K. Maier & Robert E. Kingston & Jeannie T. Lee, 2013. "High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation," Nature, Nature, vol. 504(7480), pages 465-469, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7480:d:10.1038_nature12719
    DOI: 10.1038/nature12719
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