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Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning

Author

Listed:
  • Flavio Donato

    (Friedrich Miescher Institut, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Santiago Belluco Rompani

    (Friedrich Miescher Institut, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

  • Pico Caroni

    (Friedrich Miescher Institut, Maulbeerstrasse 66, CH-4058 Basel, Switzerland)

Abstract

In adult mouse hippocampus, a learning-associated plasticity mechanism may exist that depends on the configuration of parvalbumin(PV)-expressing basket cell networks; trial and error learning initially promotes a higher fraction of cells with low PV expression, whereas learning completion promotes a higher fraction of cells with high PV expression, and these opposite configurations modulate learning and the underlying structural plasticity.

Suggested Citation

  • Flavio Donato & Santiago Belluco Rompani & Pico Caroni, 2013. "Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning," Nature, Nature, vol. 504(7479), pages 272-276, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12866
    DOI: 10.1038/nature12866
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    Cited by:

    1. Guillaume Etter & Suzanne Veldt & Jisoo Choi & Sylvain Williams, 2023. "Optogenetic frequency scrambling of hippocampal theta oscillations dissociates working memory retrieval from hippocampal spatiotemporal codes," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Karen Perez Arce & Adema Ribic & Dhrubajyoti Chowdhury & Katherine Watters & Garth J. Thompson & Basavaraju G. Sanganahalli & Elizabeth T. C. Lippard & Astrid Rohlmann & Stephen M. Strittmatter & Mark, 2023. "Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Francesco Ceccarelli & Lorenzo Ferrucci & Fabrizio Londei & Surabhi Ramawat & Emiliano Brunamonti & Aldo Genovesio, 2023. "Static and dynamic coding in distinct cell types during associative learning in the prefrontal cortex," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    4. Alicia Hernández-Vivanco & Nuria Cano-Adamuz & Alberto Sánchez-Aguilera & Alba González-Alonso & Alberto Rodríguez-Fernández & Íñigo Azcoitia & Liset Menendez de la Prida & Pablo Méndez, 2022. "Sex-specific regulation of inhibition and network activity by local aromatase in the mouse hippocampus," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Kenneth D Harris & Hannah Hochgerner & Nathan G Skene & Lorenza Magno & Linda Katona & Carolina Bengtsson Gonzales & Peter Somogyi & Nicoletta Kessaris & Sten Linnarsson & Jens Hjerling-Leffler, 2018. "Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics," PLOS Biology, Public Library of Science, vol. 16(6), pages 1-37, June.

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