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p53 status determines the role of autophagy in pancreatic tumour development

Author

Listed:
  • Mathias T. Rosenfeldt

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Jim O’Prey

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Jennifer P. Morton

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Colin Nixon

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Gillian MacKay

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Agata Mrowinska

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Amy Au

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Taranjit Singh Rai

    (Institute of Cancer Studies, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G611BD, UK)

  • Liang Zheng

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Rachel Ridgway

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Peter D. Adams

    (Institute of Cancer Studies, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G611BD, UK)

  • Kurt I. Anderson

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Eyal Gottlieb

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Owen J. Sansom

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

  • Kevin M. Ryan

    (Cancer Research UK Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK)

Abstract

In a mouse model of pancreatic tumours driven by Kras mutations, the outcome of suppressing autophagy is shown to depend on the status of p53: if p53 is intact, deletion of key autophagy genes blocks the progression of pre-cancerous lesions to aggressive carcinomas; however, in the absence of p53, loss of autophagy accelerates tumorigenesis, accompanied by deregulation of cancer cell metabolism.

Suggested Citation

  • Mathias T. Rosenfeldt & Jim O’Prey & Jennifer P. Morton & Colin Nixon & Gillian MacKay & Agata Mrowinska & Amy Au & Taranjit Singh Rai & Liang Zheng & Rachel Ridgway & Peter D. Adams & Kurt I. Anderso, 2013. "p53 status determines the role of autophagy in pancreatic tumour development," Nature, Nature, vol. 504(7479), pages 296-300, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12865
    DOI: 10.1038/nature12865
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    Cited by:

    1. Christie Y Jeon & Stephen J Pandol & Bechien Wu & Galen Cook-Wiens & Roberta A Gottlieb & Noel Bairey Merz & Marc T Goodman, 2015. "The Association of Statin Use after Cancer Diagnosis with Survival in Pancreatic Cancer Patients: A SEER-Medicare Analysis," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-13, April.

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