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Direct recording and molecular identification of the calcium channel of primary cilia

Author

Listed:
  • Paul G. DeCaen

    (Howard Hughes Medical Institute, Children’s Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Markus Delling

    (Howard Hughes Medical Institute, Children’s Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Thuy N. Vien

    (Sackler School of Graduate Biomedical Sciences, Tufts University)

  • David E. Clapham

    (Howard Hughes Medical Institute, Children’s Hospital Boston, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School)

Abstract

Primary cilia are known as specialized calcium signalling compartments on the cell surface, but the ionic permeability and other physiological properties of these protrusions are unknown—this is one of two studies identifying the ion channels that densely populate primary cilia, with direct measurements revealing cilia as a unique, functionally independent calcium signalling compartment that modulates hedgehog signalling pathways.

Suggested Citation

  • Paul G. DeCaen & Markus Delling & Thuy N. Vien & David E. Clapham, 2013. "Direct recording and molecular identification of the calcium channel of primary cilia," Nature, Nature, vol. 504(7479), pages 315-318, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12832
    DOI: 10.1038/nature12832
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    Cited by:

    1. Kodaji Ha & Nadine Mundt-Machado & Paola Bisignano & Aide Pinedo & David R. Raleigh & Gabriel Loeb & Jeremy F. Reiter & Erhu Cao & Markus Delling, 2024. "Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Sienna R. Li & Ramila E. Gulieva & Louisa Helms & Nelly M. Cruz & Thomas Vincent & Hongxia Fu & Jonathan Himmelfarb & Benjamin S. Freedman, 2022. "Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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