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Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1

Author

Listed:
  • Ioannis Manolaridis

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • Kiran Kulkarni

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Present addresses: Division of Biological Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India (K.K.); Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK (R.B.D.).)

  • Roger B. Dodd

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Present addresses: Division of Biological Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India (K.K.); Cambridge Institute for Medical Research, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK (R.B.D.).)

  • Satoshi Ogasawara

    (Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
    JST, Research Acceleration Program, Membrane Protein Crystallography Project, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan)

  • Ziguo Zhang

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • Ganka Bineva

    (Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Nicola O’Reilly

    (Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3LY, UK)

  • Sarah J. Hanrahan

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • Andrew J. Thompson

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • Nora Cronin

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

  • So Iwata

    (Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
    JST, Research Acceleration Program, Membrane Protein Crystallography Project, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan
    Imperial College, London SW7 2AZ, UK)

  • David Barford

    (Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK)

Abstract

The crystal structure of an archaeal Rce1 protein has been determined; this protein represents a novel type of intramembrane protease, with a distinct architecture and catalytic site.

Suggested Citation

  • Ioannis Manolaridis & Kiran Kulkarni & Roger B. Dodd & Satoshi Ogasawara & Ziguo Zhang & Ganka Bineva & Nicola O’Reilly & Sarah J. Hanrahan & Andrew J. Thompson & Nora Cronin & So Iwata & David Barfor, 2013. "Mechanism of farnesylated CAAX protein processing by the intramembrane protease Rce1," Nature, Nature, vol. 504(7479), pages 301-305, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12754
    DOI: 10.1038/nature12754
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