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High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Author

Listed:
  • Samuel A. Hasson

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health
    National Center for Advancing Translational Sciences, National Institutes of Health)

  • Lesley A. Kane

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Koji Yamano

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Chiu-Hui Huang

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Danielle A. Sliter

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Eugen Buehler

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Chunxin Wang

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Sabrina M. Heman-Ackah

    (NIH Center for Regenerative Medicine)

  • Tara Hessa

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

  • Rajarshi Guha

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Scott E. Martin

    (National Center for Advancing Translational Sciences, National Institutes of Health)

  • Richard J. Youle

    (Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health)

Abstract

Mitophagy is the elimination of damaged mitochondria by the autophagosome regulated by the ubiquitin ligase, parkin and the kinase PINK1; a genome-wide RNAi screen with high-content microscopy has identified new genes that have an upstream role in parkin translocation to the mitochondria.

Suggested Citation

  • Samuel A. Hasson & Lesley A. Kane & Koji Yamano & Chiu-Hui Huang & Danielle A. Sliter & Eugen Buehler & Chunxin Wang & Sabrina M. Heman-Ackah & Tara Hessa & Rajarshi Guha & Scott E. Martin & Richard J, 2013. "High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy," Nature, Nature, vol. 504(7479), pages 291-295, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7479:d:10.1038_nature12748
    DOI: 10.1038/nature12748
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