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Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness

Author

Listed:
  • Qing Li

    (University of Michigan)

  • Natacha Bohin

    (University of Michigan)

  • Tiffany Wen

    (University of Michigan)

  • Victor Ng

    (University of Michigan)

  • Jeffrey Magee

    (Howard Hughes Medical Institute, and Children's Research Institute, University of Texas Southwestern Medical Center)

  • Shann-Ching Chen

    (St Jude Children’s Research Hospital)

  • Kevin Shannon

    (University of California San Francisco)

  • Sean J. Morrison

    (Howard Hughes Medical Institute, and Children's Research Institute, University of Texas Southwestern Medical Center)

Abstract

Oncogenic Nras in mouse haematopoietic stem cells can increase the probability of cell division in some cells and decrease it in others; this bimodal activity explains how this single pre-leukaemic mutation can increase proliferation without reducing competitiveness by clonally expanding the rapidly dividing cell population and also promoting long-term self-renewal of stem cells.

Suggested Citation

  • Qing Li & Natacha Bohin & Tiffany Wen & Victor Ng & Jeffrey Magee & Shann-Ching Chen & Kevin Shannon & Sean J. Morrison, 2013. "Oncogenic Nras has bimodal effects on stem cells that sustainably increase competitiveness," Nature, Nature, vol. 504(7478), pages 143-147, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7478:d:10.1038_nature12830
    DOI: 10.1038/nature12830
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    Cited by:

    1. Alicia Villatoro & Vincent Cuminetti & Aurora Bernal & Carlos Torroja & Itziar Cossío & Alberto Benguría & Marc Ferré & Joanna Konieczny & Enrique Vázquez & Andrea Rubio & Peter Utnes & Almudena Tello, 2023. "Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation," Nature Communications, Nature, vol. 14(1), pages 1-28, December.

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