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A melanocyte lineage program confers resistance to MAP kinase pathway inhibition

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  • Cory M. Johannessen

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
    Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Harvard Medical School, 25 Shattuck Street)

  • Laura A. Johnson

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
    Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Present address: Graduate Program in Cell and Molecular Physiology, Sackler School of Graduate Biomedical Sciences, School of Medicine, Tufts University, 145 Harrison Avenue, Boston, Massachusetts 02111, USA.)

  • Federica Piccioni

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Aisha Townes

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Dennie T. Frederick

    (Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA)

  • Melanie K. Donahue

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Rajiv Narayan

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Keith T. Flaherty

    (Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA)

  • Jennifer A. Wargo

    (Medical Oncology and Dermatology, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA)

  • David E. Root

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center)

  • Levi A. Garraway

    (The Broad Institute of Harvard University and Massachusetts Institute of Technology, 7 Cambridge Center
    Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA
    Harvard Medical School, 25 Shattuck Street)

Abstract

Expression of more than 15,500 genes individually in a melanoma cell line treated with RAF, MEK, ERK or combined RAF–MEK inhibitors reveals a cyclic-AMP-dependent melanocytic signalling network associated with drug resistance; this may represent a novel therapeutic target for melanoma treatment.

Suggested Citation

  • Cory M. Johannessen & Laura A. Johnson & Federica Piccioni & Aisha Townes & Dennie T. Frederick & Melanie K. Donahue & Rajiv Narayan & Keith T. Flaherty & Jennifer A. Wargo & David E. Root & Levi A. G, 2013. "A melanocyte lineage program confers resistance to MAP kinase pathway inhibition," Nature, Nature, vol. 504(7478), pages 138-142, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7478:d:10.1038_nature12688
    DOI: 10.1038/nature12688
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    Cited by:

    1. Lorey K. Smith & Tiffany Parmenter & Margarete Kleinschmidt & Eric P. Kusnadi & Jian Kang & Claire A. Martin & Peter Lau & Riyaben Patel & Julie Lorent & David Papadopoli & Anna Trigos & Teresa Ward &, 2022. "Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
    2. Miles C. Andrews & Junna Oba & Chang-Jiun Wu & Haifeng Zhu & Tatiana Karpinets & Caitlin A. Creasy & Marie-Andrée Forget & Xiaoxing Yu & Xingzhi Song & Xizeng Mao & A. Gordon Robertson & Gabriele Roma, 2022. "Multi-modal molecular programs regulate melanoma cell state," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    3. Tom Kaufman & Erez Nitzan & Nir Firestein & Miriam Bracha Ginzberg & Seshu Iyengar & Nish Patel & Rotem Ben-Hamo & Ziv Porat & Jaryd Hunter & Andreas Hilfinger & Varda Rotter & Ran Kafri & Ravid Strau, 2022. "Visual barcodes for clonal-multiplexing of live microscopy-based assays," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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