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The protein quality control system manages plant defence compound synthesis

Author

Listed:
  • Jacob Pollier

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium)

  • Tessa Moses

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Kasteelpark Arenberg 31, Leuven-Heverlee B-3001, Belgium
    VIB, Kasteelpark Arenberg 31, Leuven-Heverlee B-3001, Belgium)

  • Miguel González-Guzmán

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium
    Present address: Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universidad Politécnica de Valencia, Ingeniero Fausto Elio s/n, Valencia 46022, Spain.)

  • Nathan De Geyter

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium)

  • Saskia Lippens

    (VIB Bio Imaging Core Gent, VIB, Technologiepark 927, Gent B-9052, Belgium
    Inflammation Research Center, VIB, Technologiepark 927, Gent B-9052, Belgium)

  • Robin Vanden Bossche

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium)

  • Peter Marhavý

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium)

  • Anna Kremer

    (VIB Bio Imaging Core Gent, VIB, Technologiepark 927, Gent B-9052, Belgium
    Inflammation Research Center, VIB, Technologiepark 927, Gent B-9052, Belgium)

  • Kris Morreel

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium)

  • Christopher J. Guérin

    (VIB Bio Imaging Core Gent, VIB, Technologiepark 927, Gent B-9052, Belgium
    Inflammation Research Center, VIB, Technologiepark 927, Gent B-9052, Belgium)

  • Aldo Tava

    (Consiglio per la Ricerca e la Sperimentazione in Agricoltura, Centro di Ricerca per le Produzioni Foraggere e Lattiero Casearie, viale Piacenza 29, Lodi 26900, Italy)

  • Wieslaw Oleszek

    (Institute of Soil Science and Plant Cultivation - State Research Institute, ul. Czartoryskich 8, Pulawy 24-100, Poland)

  • Johan M. Thevelein

    (Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, KU Leuven, Kasteelpark Arenberg 31, Leuven-Heverlee B-3001, Belgium
    VIB, Kasteelpark Arenberg 31, Leuven-Heverlee B-3001, Belgium)

  • Narciso Campos

    (Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda Diagonal 643, Barcelona 08028, Spain
    Departament de Genètica Molecular, Centre de Recerca en Agrigenòmica, Consorci CSIC-IRTA-UAB-UB, Campus UAB, Bellaterra, Barcelona 08193, Spain)

  • Sofie Goormachtig

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium)

  • Alain Goossens

    (VIB, Technologiepark 927, Gent B-9052, Belgium
    Ghent University, Technologiepark 927, Gent B-9052, Belgium)

Abstract

Plants defend themselves against attackers by producing bioactive secondary metabolites such as triterpene saponins; here, the endoplasmic-reticulum-associated degradation (ERAD) system is shown to control the activity of HMGR, the rate-limiting enzyme in the supply of the terpene precursor isopentenyl diphosphate, thereby preventing unrestrained saponin production and ensuring the integrity of plant development.

Suggested Citation

  • Jacob Pollier & Tessa Moses & Miguel González-Guzmán & Nathan De Geyter & Saskia Lippens & Robin Vanden Bossche & Peter Marhavý & Anna Kremer & Kris Morreel & Christopher J. Guérin & Aldo Tava & Wiesl, 2013. "The protein quality control system manages plant defence compound synthesis," Nature, Nature, vol. 504(7478), pages 148-152, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7478:d:10.1038_nature12685
    DOI: 10.1038/nature12685
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