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EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex

Author

Listed:
  • Haruya Ohno

    (UCSF Diabetes Center, University of California, San Francisco, 35 Medical Center Way)

  • Kosaku Shinoda

    (UCSF Diabetes Center, University of California, San Francisco, 35 Medical Center Way)

  • Kana Ohyama

    (UCSF Diabetes Center, University of California, San Francisco, 35 Medical Center Way)

  • Louis Z. Sharp

    (UCSF Diabetes Center, University of California, San Francisco, 35 Medical Center Way)

  • Shingo Kajimura

    (UCSF Diabetes Center, University of California, San Francisco, 35 Medical Center Way)

Abstract

Brown adipose tissue-enriched lysine methyltransferase EHMT1 is an essential enzyme in the PRDM16–C/EBP-β transcriptional complex that controls brown adipose cell fate and energy metabolism.

Suggested Citation

  • Haruya Ohno & Kosaku Shinoda & Kana Ohyama & Louis Z. Sharp & Shingo Kajimura, 2013. "EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex," Nature, Nature, vol. 504(7478), pages 163-167, December.
    • Handle: RePEc:nat:nature:v:504:y:2013:i:7478:d:10.1038_nature12652
    DOI: 10.1038/nature12652
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    Cited by:

    1. Yangmian Yuan & Yu Fan & Yihao Zhou & Rong Qiu & Wei Kang & Yu Liu & Yuchen Chen & Chenyu Wang & Jiajian Shi & Chengyu Liu & Yangkai Li & Min Wu & Kun Huang & Yong Liu & Ling Zheng, 2023. "Linker histone variant H1.2 is a brake on white adipose tissue browning," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Fenfen Li & Jia Jing & Miranda Movahed & Xin Cui & Qiang Cao & Rui Wu & Ziyue Chen & Liqing Yu & Yi Pan & Huidong Shi & Hang Shi & Bingzhong Xue, 2021. "Epigenetic interaction between UTX and DNMT1 regulates diet-induced myogenic remodeling in brown fat," Nature Communications, Nature, vol. 12(1), pages 1-22, December.

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