IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v503y2013i7477d10.1038_nature12686.html
   My bibliography  Save this article

Differential L1 regulation in pluripotent stem cells of humans and apes

Author

Listed:
  • Maria C. N. Marchetto

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Iñigo Narvaiza

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Ahmet M. Denli

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Christopher Benner

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Thomas A. Lazzarini

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Jason L. Nathanson

    (University of California San Diego, Stem Cell Program, Institute for Genomic Medicine, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA)

  • Apuã C. M. Paquola

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Keval N. Desai

    (University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA)

  • Roberto H. Herai

    (University of California San Diego, School of Medicine, Stem Cell Program, Sanford Consortium, MC 0695, 2880 Torrey Pines Scenic Drive, La Jolla, California 92093, USA)

  • Matthew D. Weitzman

    (University of Pennsylvania Perelman School of Medicine and Center for Cellular and Molecular Therapeutics, The Children’s Hospital of Philadelphia)

  • Gene W. Yeo

    (University of California San Diego, Stem Cell Program, Institute for Genomic Medicine, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, California 92037, USA)

  • Alysson R. Muotri

    (University of California San Diego, School of Medicine, Stem Cell Program, Sanford Consortium, MC 0695, 2880 Torrey Pines Scenic Drive, La Jolla, California 92093, USA
    Center for Academic Research and Training in Anthropogeny (CARTA), 9500 Gilman Drive)

  • Fred H. Gage

    (Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Center for Academic Research and Training in Anthropogeny (CARTA), 9500 Gilman Drive)

Abstract

Induced pluripotent stem-cell characterization reveals phenotypical differences between humans and non-human primates (NHPs): gene expression analysis shows differences in the regulation of long interspersed element-1 (L1) transposons, and in the expression of L1-restricting genes APOBEC3B and PIWIL2, correlating with higher L1 mobility in NHPs; this indicates that L1 mobility differences may have differentially shaped the human and NHP genomes.

Suggested Citation

  • Maria C. N. Marchetto & Iñigo Narvaiza & Ahmet M. Denli & Christopher Benner & Thomas A. Lazzarini & Jason L. Nathanson & Apuã C. M. Paquola & Keval N. Desai & Roberto H. Herai & Matthew D. Weitzman &, 2013. "Differential L1 regulation in pluripotent stem cells of humans and apes," Nature, Nature, vol. 503(7477), pages 525-529, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7477:d:10.1038_nature12686
    DOI: 10.1038/nature12686
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12686
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12686?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:503:y:2013:i:7477:d:10.1038_nature12686. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.