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HIV-1 evades innate immune recognition through specific cofactor recruitment

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  • Jane Rasaiyaah

    (University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK)

  • Choon Ping Tan

    (University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK)

  • Adam J. Fletcher

    (University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK)

  • Amanda J. Price

    (Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK)

  • Caroline Blondeau

    (University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK)

  • Laura Hilditch

    (University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK)

  • David A. Jacques

    (Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK)

  • David L. Selwood

    (Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK)

  • Leo C. James

    (Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK)

  • Mahdad Noursadeghi

    (University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK)

  • Greg J. Towers

    (University College London, Medical Research Council Centre for Medical Molecular Virology, University College London, 90 Gower Street, London WC1E 6BT, UK)

Abstract

Human immunodeficiency virus (HIV)-1 is shown here to depend on the recruitment to the HIV-1 capsid of specific cofactors involved in orchestrating nuclear entry and targeting; when these capsid–cofactor interactions are prevented either by virus mutation, cofactor depletion or pharmacological inhibition of cofactor recruitment, viral DNA can be detected by innate immune sensors.

Suggested Citation

  • Jane Rasaiyaah & Choon Ping Tan & Adam J. Fletcher & Amanda J. Price & Caroline Blondeau & Laura Hilditch & David A. Jacques & David L. Selwood & Leo C. James & Mahdad Noursadeghi & Greg J. Towers, 2013. "HIV-1 evades innate immune recognition through specific cofactor recruitment," Nature, Nature, vol. 503(7476), pages 402-405, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7476:d:10.1038_nature12769
    DOI: 10.1038/nature12769
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    Cited by:

    1. Hideki Saito & Hiroaki Takeuchi & Takao Masuda & Takeshi Noda & Shoji Yamaoka, 2017. "N-terminally truncated POM121C inhibits HIV-1 replication," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-23, September.

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