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The nuclear receptor Rev-erbα controls circadian thermogenic plasticity

Author

Listed:
  • Zachary Gerhart-Hines

    (Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Dan Feng

    (Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Matthew J. Emmett

    (Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Logan J. Everett

    (Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Emanuele Loro

    (Perelman School of Medicine at the University of Pennsylvania
    Pennsylvania Muscle Institute, Perelman School of Medicine at the University of Pennsylvania)

  • Erika R. Briggs

    (Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Anne Bugge

    (Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

  • Catherine Hou

    (Perelman School of Medicine at the University of Pennsylvania)

  • Christine Ferrara

    (Children’s Hospital of Philadelphia)

  • Patrick Seale

    (The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    Perelman School of Medicine at the University of Pennsylvania)

  • Daniel A. Pryma

    (Perelman School of Medicine at the University of Pennsylvania)

  • Tejvir S. Khurana

    (Perelman School of Medicine at the University of Pennsylvania
    Pennsylvania Muscle Institute, Perelman School of Medicine at the University of Pennsylvania)

  • Mitchell A. Lazar

    (Diabetes, and Metabolism, Perelman School of Medicine at the University of Pennsylvania
    The Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine at the University of Pennsylvania)

Abstract

The nuclear receptor Rev-erbα, a powerful repressor of transcription, is shown to link circadian and thermogenic networks by regulating the function of brown adipose tissue.

Suggested Citation

  • Zachary Gerhart-Hines & Dan Feng & Matthew J. Emmett & Logan J. Everett & Emanuele Loro & Erika R. Briggs & Anne Bugge & Catherine Hou & Christine Ferrara & Patrick Seale & Daniel A. Pryma & Tejvir S., 2013. "The nuclear receptor Rev-erbα controls circadian thermogenic plasticity," Nature, Nature, vol. 503(7476), pages 410-413, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7476:d:10.1038_nature12642
    DOI: 10.1038/nature12642
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    Cited by:

    1. Lasse K. Markussen & Elizabeth A. Rondini & Olivia Sveidahl Johansen & Jesper G. S. Madsen & Elahu G. Sustarsic & Ann-Britt Marcher & Jacob B. Hansen & Zachary Gerhart-Hines & James G. Granneman & Sus, 2022. "Lipolysis regulates major transcriptional programs in brown adipocytes," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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