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Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus

Author

Listed:
  • Stephanie K. Dougan

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Joseph Ashour

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Roos A. Karssemeijer

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Maximilian W. Popp

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Massachusetts Institute of Technology)

  • Ana M. Avalos

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Marta Barisa

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Arwen F. Altenburg

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Jessica R. Ingram

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Juan Jose Cragnolini

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Chunguang Guo

    (Boston Children’s Hospital, Karp Family Research Building)

  • Frederick W. Alt

    (Boston Children’s Hospital, Karp Family Research Building)

  • Rudolf Jaenisch

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center)

  • Hidde L. Ploegh

    (Whitehead Institute for Biomedical Research, 9 Cambridge Center
    Massachusetts Institute of Technology)

Abstract

Transnuclear mice are generated from B cells with a receptor specific for the haemagglutinin of influenza A virus; the authors show that influenza virus can infect and deplete haemagglutinin-specific B cells in the lung, which might confer a replicative advantage to the virus and allow it to evade an early neutralizing response.

Suggested Citation

  • Stephanie K. Dougan & Joseph Ashour & Roos A. Karssemeijer & Maximilian W. Popp & Ana M. Avalos & Marta Barisa & Arwen F. Altenburg & Jessica R. Ingram & Juan Jose Cragnolini & Chunguang Guo & Frederi, 2013. "Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus," Nature, Nature, vol. 503(7476), pages 406-409, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7476:d:10.1038_nature12637
    DOI: 10.1038/nature12637
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