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A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

Author

Listed:
  • Maria Carolina Florian

    (University of Ulm, 89091 Ulm, Germany)

  • Kalpana J. Nattamai

    (Cincinnati Children’s Hospital Medical Center and University of Cincinnati)

  • Karin Dörr

    (University of Ulm, 89091 Ulm, Germany)

  • Gina Marka

    (University of Ulm, 89091 Ulm, Germany)

  • Bettina Überle

    (University of Ulm, 89091 Ulm, Germany)

  • Virag Vas

    (University of Ulm, 89091 Ulm, Germany)

  • Christina Eckl

    (Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany)

  • Immanuel Andrä

    (Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 München, Germany)

  • Matthias Schiemann

    (Institute of Medical Microbiology, Immunology and Hygiene, Technische Universität München, 81675 München, Germany)

  • Robert A. J. Oostendorp

    (Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany)

  • Karin Scharffetter-Kochanek

    (University of Ulm, 89091 Ulm, Germany)

  • Hans Armin Kestler

    (Institut für Neuroinformatik, University of Ulm, 89091 Ulm, Germany)

  • Yi Zheng

    (Cincinnati Children’s Hospital Medical Center and University of Cincinnati)

  • Hartmut Geiger

    (University of Ulm, 89091 Ulm, Germany
    Cincinnati Children’s Hospital Medical Center and University of Cincinnati)

Abstract

This study identifies a shift from canonical to non-canonical Wnt signalling in ageing haematopoietic stem cells (HSCs); elevated expression of Wnt5a in aged HSCs has a causal role in stem-cell ageing, and this is mediated by the small Rho GTPase Cdc42.

Suggested Citation

  • Maria Carolina Florian & Kalpana J. Nattamai & Karin Dörr & Gina Marka & Bettina Überle & Virag Vas & Christina Eckl & Immanuel Andrä & Matthias Schiemann & Robert A. J. Oostendorp & Karin Scharffette, 2013. "A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing," Nature, Nature, vol. 503(7476), pages 392-396, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7476:d:10.1038_nature12631
    DOI: 10.1038/nature12631
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    Cited by:

    1. Kyung Mok Kim & Anna Mura-Meszaros & Marie Tollot & Murali Shyam Krishnan & Marco Gründl & Laura Neubert & Marco Groth & Alejo Rodriguez-Fraticelli & Arthur Flohr Svendsen & Stefano Campaner & Nico An, 2022. "Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Zihua Yu & Yuedan Zhu & Yi Chen & Chenxi Feng & Zehong Zhang & Xiaoxin Guo & Haiou Chen & Xingzhu Liu & Yu Yuan & Haiyang Chen, 2024. "Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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