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Precision is essential for efficient catalysis in an evolved Kemp eliminase

Author

Listed:
  • Rebecca Blomberg

    (Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland
    Present addresses: Corporate R&D Division, Firmenich SA, 1211 Geneva, Switzerland (R.B.); Protabit, Pasadena, California 91101, USA (H.K.P.).)

  • Hajo Kries

    (Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland)

  • Daniel M. Pinkas

    (Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland)

  • Peer R. E. Mittl

    (University of Zurich, 8057 Zurich, Switzerland)

  • Markus G. Grütter

    (University of Zurich, 8057 Zurich, Switzerland)

  • Heidi K. Privett

    (California Institute of Technology
    Present addresses: Corporate R&D Division, Firmenich SA, 1211 Geneva, Switzerland (R.B.); Protabit, Pasadena, California 91101, USA (H.K.P.).)

  • Stephen L. Mayo

    (California Institute of Technology)

  • Donald Hilvert

    (Laboratory of Organic Chemistry, ETH Zurich, 8093 Zurich, Switzerland)

Abstract

A computationally designed enzyme that was evolved to accelerate a chemical reaction 6 × 108-fold approaches the exceptional efficiency of highly optimized natural enzymes and provides valuable lessons for the creation of more sophisticated artificial catalysts.

Suggested Citation

  • Rebecca Blomberg & Hajo Kries & Daniel M. Pinkas & Peer R. E. Mittl & Markus G. Grütter & Heidi K. Privett & Stephen L. Mayo & Donald Hilvert, 2013. "Precision is essential for efficient catalysis in an evolved Kemp eliminase," Nature, Nature, vol. 503(7476), pages 418-421, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7476:d:10.1038_nature12623
    DOI: 10.1038/nature12623
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