IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v503y2013i7475d10.1038_nature12635.html
   My bibliography  Save this article

Directional tissue migration through a self-generated chemokine gradient

Author

Listed:
  • Erika Donà

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Joseph D. Barry

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Guillaume Valentin

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
    Present addresses: CABD, Universidad Pablo de Olavide, Carretera de Utrera km1, 41013 Seville, Spain (A.F.-M.); MRC National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK (G.V.).)

  • Charlotte Quirin

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Anton Khmelinskii

    (Zentrum für Molekulare Biologie der Universität Heidelberg, Deutsches Krebsforschungszentrum, DKFZ–ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Andreas Kunze

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Sevi Durdu

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Lionel R. Newton

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Ana Fernandez-Minan

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany
    Present addresses: CABD, Universidad Pablo de Olavide, Carretera de Utrera km1, 41013 Seville, Spain (A.F.-M.); MRC National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK (G.V.).)

  • Wolfgang Huber

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

  • Michael Knop

    (Zentrum für Molekulare Biologie der Universität Heidelberg, Deutsches Krebsforschungszentrum, DKFZ–ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany)

  • Darren Gilmour

    (EMBL Heidelberg, Meyerhofstraße 1, 69117 Heidelberg, Germany)

Abstract

It is widely accepted that migrating cells and tissues navigate along pre-patterned chemoattractant gradients; here it is shown that migrating tissues can also determine their own direction by generating local gradients of chemokine activity, via polarized receptor-mediated internalization, that are sufficient to ensure robust collective migration.

Suggested Citation

  • Erika Donà & Joseph D. Barry & Guillaume Valentin & Charlotte Quirin & Anton Khmelinskii & Andreas Kunze & Sevi Durdu & Lionel R. Newton & Ana Fernandez-Minan & Wolfgang Huber & Michael Knop & Darren , 2013. "Directional tissue migration through a self-generated chemokine gradient," Nature, Nature, vol. 503(7475), pages 285-289, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7475:d:10.1038_nature12635
    DOI: 10.1038/nature12635
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12635
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12635?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:503:y:2013:i:7475:d:10.1038_nature12635. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.