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Inhibitory signalling to the Arp2/3 complex steers cell migration

Author

Listed:
  • Irene Dang

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Roman Gorelik

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Carla Sousa-Blin

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Emmanuel Derivery

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Christophe Guérin

    (Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV), Laboratoire de Physiologie Cellulaire et Végétale, CNRS/CEA/INRA/UJF, Grenoble 38054, France)

  • Joern Linkner

    (Institute for Biophysical Chemistry, Hannover Medical School, Hannover 30625, Germany)

  • Maria Nemethova

    (Institute of Molecular Biotechnology, Vienna 1030, Austria)

  • Julien G. Dumortier

    (INSERM U1024, CNRS UMR8197, ENS, Institut de Biologie de l‘ENS, Paris 75005, France)

  • Florence A. Giger

    (INSERM U1024, CNRS UMR8197, ENS, Institut de Biologie de l‘ENS, Paris 75005, France)

  • Tamara A. Chipysheva

    (Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Russia)

  • Valeria D. Ermilova

    (Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Russia)

  • Sophie Vacher

    (Oncogenetic Laboratory, Institut Curie, Hôpital René Huguenin, Saint-Cloud 92210, France)

  • Valérie Campanacci

    (Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Isaline Herrada

    (Laboratoire de Biologie Structurale et Radiobiologie (iBiTec-S), CNRS URA2096, CEA Saclay, Gif-sur-Yvette 91190, France)

  • Anne-Gaelle Planson

    (Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Susan Fetics

    (Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Véronique Henriot

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Violaine David

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Ksenia Oguievetskaia

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Goran Lakisic

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Fabienne Pierre

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Anika Steffen

    (Institute of Genetics, University of Bonn, Bonn 53115, Germany)

  • Adeline Boyreau

    (Institut des Systèmes Complexes & NeD, Institut de Neurobiologie Alfred Fessard, CNRS UPR3294, Gif-sur-Yvette 91190, France)

  • Nadine Peyriéras

    (Institut des Systèmes Complexes & NeD, Institut de Neurobiologie Alfred Fessard, CNRS UPR3294, Gif-sur-Yvette 91190, France)

  • Klemens Rottner

    (Institute of Genetics, University of Bonn, Bonn 53115, Germany
    Helmholtz Centre for Infection Research, Braunschweig 38124, Germany)

  • Sophie Zinn-Justin

    (Laboratoire de Biologie Structurale et Radiobiologie (iBiTec-S), CNRS URA2096, CEA Saclay, Gif-sur-Yvette 91190, France)

  • Jacqueline Cherfils

    (Group Small G Proteins, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

  • Ivan Bièche

    (Oncogenetic Laboratory, Institut Curie, Hôpital René Huguenin, Saint-Cloud 92210, France)

  • Antonina Y. Alexandrova

    (Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Russia)

  • Nicolas B. David

    (INSERM U1024, CNRS UMR8197, ENS, Institut de Biologie de l‘ENS, Paris 75005, France)

  • J. Victor Small

    (Institute of Molecular Biotechnology, Vienna 1030, Austria)

  • Jan Faix

    (Institute for Biophysical Chemistry, Hannover Medical School, Hannover 30625, Germany)

  • Laurent Blanchoin

    (Institut de Recherches en Technologies et Sciences pour le Vivant (iRTSV), Laboratoire de Physiologie Cellulaire et Végétale, CNRS/CEA/INRA/UJF, Grenoble 38054, France)

  • Alexis Gautreau

    (Group Cytoskeleton in Cell Morphogenesis, Laboratoire d’Enzymologie et Biochimie Structurales, CNRS UPR3082, Gif-sur-Yvette 91190, France)

Abstract

A new protein, Arpin, is identified that inhibits the Arp2/3 complex and controls cell migration by decreasing cell speed and the directional persistence of migration; this inhibitory circuit is under the control of the small GTPase Rac1, and Arpin depletion causes faster lamellipodia protrusion and increased cell migration.

Suggested Citation

  • Irene Dang & Roman Gorelik & Carla Sousa-Blin & Emmanuel Derivery & Christophe Guérin & Joern Linkner & Maria Nemethova & Julien G. Dumortier & Florence A. Giger & Tamara A. Chipysheva & Valeria D. Er, 2013. "Inhibitory signalling to the Arp2/3 complex steers cell migration," Nature, Nature, vol. 503(7475), pages 281-284, November.
    • Handle: RePEc:nat:nature:v:503:y:2013:i:7475:d:10.1038_nature12611
    DOI: 10.1038/nature12611
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    Cited by:

    1. Rayane Dibsy & Erwan Bremaud & Johnson Mak & Cyril Favard & Delphine Muriaux, 2023. "HIV-1 diverts cortical actin for particle assembly and release," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Fred E. Fregoso & Malgorzata Boczkowska & Grzegorz Rebowski & Peter J. Carman & Trevor Eeuwen & Roberto Dominguez, 2023. "Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Yanan Wang & Giovanni Chiappetta & Raphaël Guérois & Yijun Liu & Stéphane Romero & Daniel J. Boesch & Matthias Krause & Claire A. Dessalles & Avin Babataheri & Abdul I. Barakat & Baoyu Chen & Joelle V, 2023. "PPP2R1A regulates migration persistence through the NHSL1-containing WAVE Shell Complex," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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