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Discovery of new enzymes and metabolic pathways by using structure and genome context

Author

Listed:
  • Suwen Zhao

    (University of California)

  • Ritesh Kumar

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign)

  • Ayano Sakai

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign)

  • Matthew W. Vetting

    (Albert Einstein College of Medicine)

  • B. McKay Wood

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign)

  • Shoshana Brown

    (University of California)

  • Jeffery B. Bonanno

    (Albert Einstein College of Medicine)

  • Brandan S. Hillerich

    (Albert Einstein College of Medicine)

  • Ronald D. Seidel

    (Albert Einstein College of Medicine)

  • Patricia C. Babbitt

    (University of California)

  • Steven C. Almo

    (Albert Einstein College of Medicine)

  • Jonathan V. Sweedler

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • John A. Gerlt

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • John E. Cronan

    (Institute for Genomic Biology, University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign
    University of Illinois at Urbana-Champaign)

  • Matthew P. Jacobson

    (University of California)

Abstract

Pathway docking (in silico docking of metabolites to several enzymes and binding proteins in a metabolic pathway) enables the discovery of a catabolic pathway for the osmolyte trans-4-hydroxy-l-proline betaine.

Suggested Citation

  • Suwen Zhao & Ritesh Kumar & Ayano Sakai & Matthew W. Vetting & B. McKay Wood & Shoshana Brown & Jeffery B. Bonanno & Brandan S. Hillerich & Ronald D. Seidel & Patricia C. Babbitt & Steven C. Almo & Jo, 2013. "Discovery of new enzymes and metabolic pathways by using structure and genome context," Nature, Nature, vol. 502(7473), pages 698-702, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7473:d:10.1038_nature12576
    DOI: 10.1038/nature12576
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    Cited by:

    1. Nikos Pinotsis & Anna Krüger & Nicolas Tomas & Spyros D. Chatziefthymiou & Claudia Litz & Simon Arnold Mortensen & Mamadou Daffé & Hedia Marrakchi & Garabed Antranikian & Matthias Wilmanns, 2023. "Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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