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The nexus of chromatin regulation and intermediary metabolism

Author

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  • Philipp Gut

    (Gladstone Institutes, University of California)

  • Eric Verdin

    (Gladstone Institutes, University of California)

Abstract

Living organisms and individual cells continuously adapt to changes in their environment. Those changes are particularly sensitive to fluctuations in the availability of energy substrates. The cellular transcriptional machinery and its chromatin-associated proteins integrate environmental inputs to mediate homeostatic responses through gene regulation. Numerous connections between products of intermediary metabolism and chromatin proteins have recently been identified. Chromatin modifications that occur in response to metabolic signals are dynamic or stable and might even be inherited transgenerationally. These emerging concepts have biological relevance to tissue homeostasis, disease and ageing.

Suggested Citation

  • Philipp Gut & Eric Verdin, 2013. "The nexus of chromatin regulation and intermediary metabolism," Nature, Nature, vol. 502(7472), pages 489-498, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12752
    DOI: 10.1038/nature12752
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    Cited by:

    1. Jiangbo Song & Zhiquan Li & Lei Zhou & Xin Chen & Wei Qi Guinevere Sew & Héctor Herranz & Zilu Ye & Jesper Velgaard Olsen & Yuan Li & Marianne Nygaard & Kaare Christensen & Xiaoling Tong & Vilhelm A. , 2024. "FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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