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Chromatin dynamics during cellular reprogramming

Author

Listed:
  • Effie Apostolou

    (Massachusetts General Hospital Center for Regenerative Medicine
    Harvard Stem Cell Institute
    Howard Hughes Medical Institute
    Harvard University and Harvard Medical School)

  • Konrad Hochedlinger

    (Massachusetts General Hospital Center for Regenerative Medicine
    Harvard Stem Cell Institute
    Howard Hughes Medical Institute
    Harvard University and Harvard Medical School)

Abstract

Induced pluripotency is a powerful tool to derive patient-specific stem cells. In addition, it provides a unique assay to study the interplay between transcription factors and chromatin structure. Here, we review the latest insights into chromatin dynamics that are inherent to induced pluripotency. Moreover, we compare and contrast these events with other physiological and pathological processes that involve changes in chromatin and cell state, including germ cell maturation and tumorigenesis. We propose that an integrated view of these seemingly diverse processes could provide mechanistic insights into cell fate transitions in general and might lead to new approaches in regenerative medicine and cancer treatment.

Suggested Citation

  • Effie Apostolou & Konrad Hochedlinger, 2013. "Chromatin dynamics during cellular reprogramming," Nature, Nature, vol. 502(7472), pages 462-471, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12749
    DOI: 10.1038/nature12749
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    Cited by:

    1. Moriyah Naama & Moran Rahamim & Valery Zayat & Shulamit Sebban & Ahmed Radwan & Dana Orzech & Rachel Lasry & Annael Ifrah & Mohammad Jaber & Ofra Sabag & Hazar Yassen & Areej Khatib & Silvina Epsztejn, 2023. "Pluripotency-independent induction of human trophoblast stem cells from fibroblasts," Nature Communications, Nature, vol. 14(1), pages 1-22, December.

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