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A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use

Author

Listed:
  • Sihao Liu

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

  • Jonathan D. Brown

    (Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Kristopher J. Stanya

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

  • Edwin Homan

    (Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA)

  • Mathias Leidl

    (Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA)

  • Karen Inouye

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

  • Prerna Bhargava

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

  • Matthew R. Gangl

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

  • Lingling Dai

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Good Clinical Practice Office of XiangYa Hospital and Institute of Clinical Pharmacology, Central South University, Changsha, Hunan 410000, China)

  • Ben Hatano

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Present address: Clinical Science Department, Research & Development, AstraZeneca K.K., 1-1- 88 Ohyodo-Naka, Kita-Ku, Osaka 531-0076, Japan.)

  • Gökhan S. Hotamisligil

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

  • Alan Saghatelian

    (Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA)

  • Jorge Plutzky

    (Brigham and Women’s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA)

  • Chih-Hao Lee

    (Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA)

Abstract

How the liver communicates with peripheral tissues to achieve metabolic homeostasis is poorly defined; here the authors show that the nuclear hormone receptor PPARδ regulates de novo lipogenesis in the liver and orchestrates fat use by muscle via a circulating lipid.

Suggested Citation

  • Sihao Liu & Jonathan D. Brown & Kristopher J. Stanya & Edwin Homan & Mathias Leidl & Karen Inouye & Prerna Bhargava & Matthew R. Gangl & Lingling Dai & Ben Hatano & Gökhan S. Hotamisligil & Alan Sagha, 2013. "A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use," Nature, Nature, vol. 502(7472), pages 550-554, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12710
    DOI: 10.1038/nature12710
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    Cited by:

    1. Rongfeng Huang & Jianghui Chen & Meiyu Zhou & Haoran Xin & Sin Man Lam & Xiaoqing Jiang & Jie Li & Fang Deng & Guanghou Shui & Zhihui Zhang & Min-Dian Li, 2023. "Multi-omics profiling reveals rhythmic liver function shaped by meal timing," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Xiaodi Hu & Mingwei Sun & Qian Chen & Yixia Zhao & Na Liang & Siyuan Wang & Pengbin Yin & Yuanping Yang & Sin Man Lam & Qianying Zhang & Alimujiang Tudiyusufu & Yingying Gu & Xin Wan & Meihong Chen & , 2023. "Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Samuel A. Druzak & Matteo Tardelli & Suzanne G. Mays & Mireille El Bejjani & Xulie Mo & Kristal M. Maner-Smith & Thomas Bowen & Michael L. Cato & Matthew C. Tillman & Akiko Sugiyama & Yang Xie & Haian, 2023. "Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Yanying Wang & Jing Wang & Xiaoyu Li & Xushen Xiong & Jianyi Wang & Ziheng Zhou & Xiaoxiao Zhu & Yang Gu & Dan Dominissini & Lei He & Yong Tian & Chengqi Yi & Zusen Fan, 2021. "N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism," Nature Communications, Nature, vol. 12(1), pages 1-19, December.

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