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MX2 is an interferon-induced inhibitor of HIV-1 infection

Author

Listed:
  • Melissa Kane

    (Aaron Diamond AIDS Research Center
    Laboratory of Retrovirology, The Rockefeller University)

  • Shalini S. Yadav

    (Aaron Diamond AIDS Research Center
    Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute
    Present addresses: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9048, USA (J.W.S.); MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK (S.J.W.); Weill Cornell Medical College, 525 East 68th street, New York, New York 10025, USA (S.S.Y.).)

  • Julia Bitzegeio

    (Aaron Diamond AIDS Research Center
    Laboratory of Retrovirology, The Rockefeller University)

  • Sebla B. Kutluay

    (Aaron Diamond AIDS Research Center
    Laboratory of Retrovirology, The Rockefeller University)

  • Trinity Zang

    (Aaron Diamond AIDS Research Center
    Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute)

  • Sam J. Wilson

    (Aaron Diamond AIDS Research Center
    Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute
    Present addresses: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9048, USA (J.W.S.); MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK (S.J.W.); Weill Cornell Medical College, 525 East 68th street, New York, New York 10025, USA (S.S.Y.).)

  • John W. Schoggins

    (Center for the Study of Hepatitis C, The Rockefeller University
    Present addresses: University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9048, USA (J.W.S.); MRC Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK (S.J.W.); Weill Cornell Medical College, 525 East 68th street, New York, New York 10025, USA (S.S.Y.).)

  • Charles M. Rice

    (Center for the Study of Hepatitis C, The Rockefeller University)

  • Masahiro Yamashita

    (Aaron Diamond AIDS Research Center)

  • Theodora Hatziioannou

    (Aaron Diamond AIDS Research Center)

  • Paul D. Bieniasz

    (Aaron Diamond AIDS Research Center
    Laboratory of Retrovirology, The Rockefeller University
    Howard Hughes Medical Institute)

Abstract

MX2 is shown to be an interferon-induced inhibitor of HIV-1 infection, and this antiviral activity may involve the inhibition of nuclear import of subviral complexes.

Suggested Citation

  • Melissa Kane & Shalini S. Yadav & Julia Bitzegeio & Sebla B. Kutluay & Trinity Zang & Sam J. Wilson & John W. Schoggins & Charles M. Rice & Masahiro Yamashita & Theodora Hatziioannou & Paul D. Bienias, 2013. "MX2 is an interferon-induced inhibitor of HIV-1 infection," Nature, Nature, vol. 502(7472), pages 563-566, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12653
    DOI: 10.1038/nature12653
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