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Spatial organization within a niche as a determinant of stem-cell fate

Author

Listed:
  • Panteleimon Rompolas

    (Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine)

  • Kailin R. Mesa

    (Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine)

  • Valentina Greco

    (Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine)

Abstract

Stem-cell niches in mammalian tissues are often heterogeneous and compartmentalized; however, whether distinct niche locations determine different stem-cell fates remains unclear. To test this hypothesis, here we use the mouse hair follicle niche and combine intravital microscopy with genetic lineage tracing to re-visit the same stem-cell lineages, from their exact place of origin, throughout regeneration in live mice. Using this method, we show directly that the position of a stem cell within the hair follicle niche can predict whether it is likely to remain uncommitted, generate precursors or commit to a differentiated fate. Furthermore, using laser ablation we demonstrate that hair follicle stem cells are dispensable for regeneration, and that epithelial cells, which do not normally participate in hair growth, re-populate the lost stem-cell compartment and sustain hair regeneration. This study provides a general model for niche-induced fate determination in adult tissues.

Suggested Citation

  • Panteleimon Rompolas & Kailin R. Mesa & Valentina Greco, 2013. "Spatial organization within a niche as a determinant of stem-cell fate," Nature, Nature, vol. 502(7472), pages 513-518, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12602
    DOI: 10.1038/nature12602
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    Cited by:

    1. Akshay Patel & Yicong Wu & Xiaofei Han & Yijun Su & Tim Maugel & Hari Shroff & Sougata Roy, 2022. "Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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