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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

Author

Listed:
  • Aaron M. Ring

    (Stanford University
    Stanford University)

  • Aashish Manglik

    (Stanford University)

  • Andrew C. Kruse

    (Stanford University)

  • Michael D. Enos

    (Stanford University
    Stanford University)

  • William I. Weis

    (Stanford University
    Stanford University)

  • K. Christopher Garcia

    (Stanford University
    Stanford University
    Howard Hughes Medical Institute, Stanford University School of Medicine)

  • Brian K. Kobilka

    (Stanford University)

Abstract

Here, by developing a high-affinity camelid antibody fragment that stabilizes the active state of the β2-adrenoceptor, the X-ray crystal structures of the receptor in complex with three agonists, including adrenaline, were determined.

Suggested Citation

  • Aaron M. Ring & Aashish Manglik & Andrew C. Kruse & Michael D. Enos & William I. Weis & K. Christopher Garcia & Brian K. Kobilka, 2013. "Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody," Nature, Nature, vol. 502(7472), pages 575-579, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7472:d:10.1038_nature12572
    DOI: 10.1038/nature12572
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    Citations

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    Cited by:

    1. Xinyu Xu & Jeremy Shonberg & Jonas Kaindl & Mary J. Clark & Anne Stößel & Luis Maul & Daniel Mayer & Harald Hübner & Kunio Hirata & A. J. Venkatakrishnan & Ron O. Dror & Brian K. Kobilka & Roger K. Su, 2023. "Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Minfei Su & Jinan Wang & Guoqing Xiang & Hung Nguyen Do & Joshua Levitz & Yinglong Miao & Xin-Yun Huang, 2023. "Structural basis of agonist specificity of α1A-adrenergic receptor," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Xin Chen & Kexin Wang & Jianfang Chen & Chao Wu & Jun Mao & Yuanpeng Song & Yijing Liu & Zhenhua Shao & Xuemei Pu, 2024. "Integrative residue-intuitive machine learning and MD Approach to Unveil Allosteric Site and Mechanism for β2AR," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Yosuke Toyoda & Angqi Zhu & Fang Kong & Sisi Shan & Jiawei Zhao & Nan Wang & Xiaoou Sun & Linqi Zhang & Chuangye Yan & Brian K. Kobilka & Xiangyu Liu, 2023. "Structural basis of α1A-adrenergic receptor activation and recognition by an extracellular nanobody," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    5. Jie Heng & Yunfei Hu & Guillermo Pérez-Hernández & Asuka Inoue & Jiawei Zhao & Xiuyan Ma & Xiaoou Sun & Kouki Kawakami & Tatsuya Ikuta & Jienv Ding & Yujie Yang & Lujia Zhang & Sijia Peng & Xiaogang N, 2023. "Function and dynamics of the intrinsically disordered carboxyl terminus of β2 adrenergic receptor," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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