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Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration

Author

Listed:
  • Marenda A. Wilson

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • YoungHo Kwon

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Yuanyuan Xu

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Woo-Hyun Chung

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    College of Pharmacy, Duksung Women’s University, Seoul 132-714, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa 52242-1324, USA (A.M.).
    College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa 52242-1324, USA (A.M.).)

  • Peter Chi

    (Institute of Biochemical Sciences, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan
    Institute of Biological Chemistry, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan)

  • Hengyao Niu

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Ryan Mayle

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Xuefeng Chen

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

  • Anna Malkova

    (School of Science, IUPUI, Indianapolis, Indiana 46202, USA
    Present addresses: College of Pharmacy, Duksung Women’s University, Seoul 132-714, South Korea (W.-H.C.); Department of Biology, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa 52242-1324, USA (A.M.).)

  • Patrick Sung

    (Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA)

  • Grzegorz Ira

    (Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA)

Abstract

This paper demonstrates that Pif1 helicase works with polymerase d to promote DNA synthesis through a migrating D-loop, a mechanism used to copy tens of kilobases during repair of chromosome breaks by break-induced replication (BIR).

Suggested Citation

  • Marenda A. Wilson & YoungHo Kwon & Yuanyuan Xu & Woo-Hyun Chung & Peter Chi & Hengyao Niu & Ryan Mayle & Xuefeng Chen & Anna Malkova & Patrick Sung & Grzegorz Ira, 2013. "Pif1 helicase and Polδ promote recombination-coupled DNA synthesis via bubble migration," Nature, Nature, vol. 502(7471), pages 393-396, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7471:d:10.1038_nature12585
    DOI: 10.1038/nature12585
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    Cited by:

    1. Dayana E. Salas-Leiva & Eelco C. Tromer & Bruce A. Curtis & Jon Jerlström-Hultqvist & Martin Kolisko & Zhenzhen Yi & Joan S. Salas-Leiva & Lucie Gallot-Lavallée & Shelby K. Williams & Geert J. P. L. K, 2021. "Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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