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Vinylogous chain branching catalysed by a dedicated polyketide synthase module

Author

Listed:
  • Tom Bretschneider

    (Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany)

  • Joel B. Heim

    (Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany)

  • Daniel Heine

    (Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany)

  • Robert Winkler

    (Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany)

  • Benjamin Busch

    (Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany)

  • Björn Kusebauch

    (Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany)

  • Thilo Stehle

    (Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany
    Vanderbilt University School of Medicine)

  • Georg Zocher

    (Interfaculty Institute of Biochemistry, Eberhard Karls University Tübingen, Tübingen 72076, Germany)

  • Christian Hertweck

    (Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena 07745, Germany
    Chair for Natural Product Chemistry, Friedrich Schiller University, Jena 07737, Germany)

Abstract

This study shows the structural and biochemical characterization of a new type of polyketide synthase module that catalyses the vinylogous addition of a malonyl unit to an unsaturated thioester, generating a branch in the growing polyketide chain; this characterization provides a mechanism by which the structural diversity of polyketide natural products can be increased.

Suggested Citation

  • Tom Bretschneider & Joel B. Heim & Daniel Heine & Robert Winkler & Benjamin Busch & Björn Kusebauch & Thilo Stehle & Georg Zocher & Christian Hertweck, 2013. "Vinylogous chain branching catalysed by a dedicated polyketide synthase module," Nature, Nature, vol. 502(7469), pages 124-128, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7469:d:10.1038_nature12588
    DOI: 10.1038/nature12588
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    Cited by:

    1. Hong Jie Zhu & Bo Zhang & Wanqing Wei & Shuang He Liu & Lang Xiang & Jiapeng Zhu & Rui Hua Jiao & Yasuhiro Igarashi & Ghader Bashiri & Yong Liang & Ren Xiang Tan & Hui Ming Ge, 2022. "AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Jialiang Wang & Xiaojie Wang & Xixi Li & LiangLiang Kong & Zeqian Du & Dandan Li & Lixia Gou & Hao Wu & Wei Cao & Xiaozheng Wang & Shuangjun Lin & Ting Shi & Zixin Deng & Zhijun Wang & Jingdan Liang, 2023. "C–N bond formation by a polyketide synthase," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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