IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v502y2013i7469d10.1038_nature12538.html
   My bibliography  Save this article

Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters

Author

Listed:
  • Guus B. Erkens

    (University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands)

  • Inga Hänelt

    (University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    University of Groningen, Groningen Biomolecular Science and Biotechnology Institute, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    Present address: Goethe-University Frankfurt, Molecular Microbiology and Bioenergetics, Institute of Molecular Biosciences, Max-von-Laue-Strasse 9, 60438 Frankfurt am Main, Germany.)

  • Joris M. H. Goudsmits

    (University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands)

  • Dirk Jan Slotboom

    (University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    University of Groningen, Groningen Biomolecular Science and Biotechnology Institute, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    University of Groningen, Centre for Synthetic Biology, Nijenborgh 4, 9747 AG Groningen, The Netherlands)

  • Antoine M. van Oijen

    (University of Groningen, Zernike Institute for Advanced Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    University of Groningen, Groningen Biomolecular Science and Biotechnology Institute, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    University of Groningen, Centre for Synthetic Biology, Nijenborgh 4, 9747 AG Groningen, The Netherlands)

Abstract

Glutamate transporters are integral membrane proteins that facilitate neurotransmitter uptake from the synaptic cleft into the cytoplasm of glial cells and neurons, the mechanism of transport involves transitions between extracellular- and intracellular-facing conformations; here the authors used single-molecule fluorescence resonance energy transfer imaging to directly observe conformational dynamics in trimers of a bacterial homologue of glutamate transporters that was embedded in the membrane.

Suggested Citation

  • Guus B. Erkens & Inga Hänelt & Joris M. H. Goudsmits & Dirk Jan Slotboom & Antoine M. van Oijen, 2013. "Unsynchronised subunit motion in single trimeric sodium-coupled aspartate transporters," Nature, Nature, vol. 502(7469), pages 119-123, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7469:d:10.1038_nature12538
    DOI: 10.1038/nature12538
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12538
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12538?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Paul David Harris & Alessandra Narducci & Christian Gebhardt & Thorben Cordes & Shimon Weiss & Eitan Lerner, 2022. "Multi-parameter photon-by-photon hidden Markov modeling," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. David B. Sauer & Jennifer J. Marden & Joseph C. Sudar & Jinmei Song & Christopher Mulligan & Da-Neng Wang, 2022. "Structural basis of ion – substrate coupling in the Na+-dependent dicarboxylate transporter VcINDY," Nature Communications, Nature, vol. 13(1), pages 1-9, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:502:y:2013:i:7469:d:10.1038_nature12538. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.