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Immune clearance of highly pathogenic SIV infection

Author

Listed:
  • Scott G. Hansen

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Michael Piatak Jr

    (AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA)

  • Abigail B. Ventura

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Colette M. Hughes

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Roxanne M. Gilbride

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Julia C. Ford

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Kelli Oswald

    (AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA)

  • Rebecca Shoemaker

    (AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA)

  • Yuan Li

    (AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA)

  • Matthew S. Lewis

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Awbrey N. Gilliam

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Guangwu Xu

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Nathan Whizin

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Benjamin J. Burwitz

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Shannon L. Planer

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • John M. Turner

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Alfred W. Legasse

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Michael K. Axthelm

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Jay A. Nelson

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Klaus Früh

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Jonah B. Sacha

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

  • Jacob D. Estes

    (AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA)

  • Brandon F. Keele

    (AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA)

  • Paul T. Edlefsen

    (Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center)

  • Jeffrey D. Lifson

    (AIDS and Cancer Virus Program, SAIC Frederick, Inc., Frederick National Laboratory, Frederick, Maryland 21702, USA)

  • Louis J. Picker

    (Vaccine and Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University)

Abstract

Cellular immune responses in rhesus macaques (Macaca mulatta) vaccinated with cytomegalovirus vectors expressing SIV proteins are able to stringently control highly pathogenic SIV infection, regardless of the route of challenge, after systemic spread; immunological and virological analyses of protected macaques followed for up to 3 years suggest that persistent immune surveillance by vaccine-elicited immune responses may have cleared the infection.

Suggested Citation

  • Scott G. Hansen & Michael Piatak Jr & Abigail B. Ventura & Colette M. Hughes & Roxanne M. Gilbride & Julia C. Ford & Kelli Oswald & Rebecca Shoemaker & Yuan Li & Matthew S. Lewis & Awbrey N. Gilliam &, 2013. "Immune clearance of highly pathogenic SIV infection," Nature, Nature, vol. 502(7469), pages 100-104, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7469:d:10.1038_nature12519
    DOI: 10.1038/nature12519
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    Cited by:

    1. Fangzhu Zhao & Zachary T. Berndsen & Nuria Pedreño-Lopez & Alison Burns & Joel D. Allen & Shawn Barman & Wen-Hsin Lee & Srirupa Chakraborty & Sandrasegaram Gnanakaran & Leigh M. Sewall & Gabriel Ozoro, 2022. "Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Daniel Malouli & Meenakshi Tiwary & Roxanne M. Gilbride & David W. Morrow & Colette M. Hughes & Andrea Selseth & Toni Penney & Priscila Castanha & Megan Wallace & Yulia Yeung & Morgan Midgett & Connor, 2024. "Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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