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Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2

Author

Listed:
  • Brett H. Herzog

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
    University of Oklahoma Health Sciences Center)

  • Jianxin Fu

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
    Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China)

  • Stephen J. Wilson

    (Cardiovascular Research Institute, University of California)

  • Paul R. Hess

    (University of Pennsylvania)

  • Aslihan Sen

    (University of Pennsylvania)

  • J. Michael McDaniel

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation)

  • Yanfang Pan

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
    University of Oklahoma Health Sciences Center)

  • Minjia Sheng

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation)

  • Tadayuki Yago

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation)

  • Robert Silasi-Mansat

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation)

  • Samuel McGee

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation)

  • Frauke May

    (University Hospital Wurzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, 97080 Wurzburg, Germany)

  • Bernhard Nieswandt

    (University Hospital Wurzburg and Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, 97080 Wurzburg, Germany)

  • Andrew J. Morris

    (University of Kentucky and Lexington Veterans Affairs Medical Center)

  • Florea Lupu

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation)

  • Shaun R. Coughlin

    (Cardiovascular Research Institute, University of California)

  • Rodger P. McEver

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
    University of Oklahoma Health Sciences Center)

  • Hong Chen

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
    University of Oklahoma Health Sciences Center)

  • Mark L. Kahn

    (University of Pennsylvania)

  • Lijun Xia

    (Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation
    University of Oklahoma Health Sciences Center
    Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China
    Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China)

Abstract

A transmembrane O-glycoprotein podoplanin (PDPN) expressed on fibroblastic reticular cells is the activating ligand for platelet receptor CLEC-2; this interaction leads to perivenular release of sphingosine-1-phosphate and expression of VE-cadherin on high endothelial venules, a key process for the maintenance of vascular integrity in lymph nodes.

Suggested Citation

  • Brett H. Herzog & Jianxin Fu & Stephen J. Wilson & Paul R. Hess & Aslihan Sen & J. Michael McDaniel & Yanfang Pan & Minjia Sheng & Tadayuki Yago & Robert Silasi-Mansat & Samuel McGee & Frauke May & Be, 2013. "Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2," Nature, Nature, vol. 502(7469), pages 105-109, October.
    • Handle: RePEc:nat:nature:v:502:y:2013:i:7469:d:10.1038_nature12501
    DOI: 10.1038/nature12501
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