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Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes

Author

Listed:
  • Lingchuan Hu

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

  • Tae Moon Kim

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

  • Mi Young Son

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

  • Sung-A Kim

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

  • Cory L. Holland

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

  • Satoshi Tateishi

    (Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Honjo 2-2-1 Kumamoto 860-0811, Japan)

  • Dong Hyun Kim

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

  • P. Renee Yew

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

  • Cristina Montagna

    (Albert Einstein College of Medicine of Yeshiva University)

  • Lavinia C. Dumitrache

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA
    Present address: Department of Genetics & Tumor Cell Biology M/S 331, St Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA.)

  • Paul Hasty

    (The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, Texas 78245-3207, USA)

Abstract

Stalling of replication forks in sequences that have non-allelic repeats can lead to genomic rearrangements; here two pathways consistent with homologous recombination and error-free post-replication repair fuse identical and mismatched repeats, respectively, thus inducing chromosomal rearrangements in mouse embryonic stem cells.

Suggested Citation

  • Lingchuan Hu & Tae Moon Kim & Mi Young Son & Sung-A Kim & Cory L. Holland & Satoshi Tateishi & Dong Hyun Kim & P. Renee Yew & Cristina Montagna & Lavinia C. Dumitrache & Paul Hasty, 2013. "Two replication fork maintenance pathways fuse inverted repeats to rearrange chromosomes," Nature, Nature, vol. 501(7468), pages 569-572, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7468:d:10.1038_nature12500
    DOI: 10.1038/nature12500
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