IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v501y2013i7468d10.1038_nature12471.html
   My bibliography  Save this article

Wapl is an essential regulator of chromatin structure and chromosome segregation

Author

Listed:
  • Antonio Tedeschi

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Gordana Wutz

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Sébastien Huet

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany
    CNRS, UMR 6290, Institut Génétique et Développement de Rennes, F-35043 Rennes, France
    Université de Rennes 1, Université Européenne de Bretagne, Structure fédérative de recherche Biosit, Faculté de Médecine, F-35043 Rennes, France)

  • Markus Jaritz

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Annelie Wuensche

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany)

  • Erika Schirghuber

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Iain Finley Davidson

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Wen Tang

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • David A. Cisneros

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Max F. Perutz Laboratories, University of Vienna, Austria, Dr. Bohr-Gasse 9, 1030 Vienna, Austria
    Research Platform Quantum Phenomena & Nanoscale Biological Systems (QuNaBioS), University of Vienna, Dr. Bohr-Gasse 7-9, 1030 Vienna, Austria)

  • Venugopal Bhaskara

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Tomoko Nishiyama

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Alipasha Vaziri

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Max F. Perutz Laboratories, University of Vienna, Austria, Dr. Bohr-Gasse 9, 1030 Vienna, Austria
    Research Platform Quantum Phenomena & Nanoscale Biological Systems (QuNaBioS), University of Vienna, Dr. Bohr-Gasse 7-9, 1030 Vienna, Austria)

  • Anton Wutz

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Jan Ellenberg

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany)

  • Jan-Michael Peters

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

Abstract

Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes; the findings suggest that cohesin could have an architectural role in interphase chromosome organization.

Suggested Citation

  • Antonio Tedeschi & Gordana Wutz & Sébastien Huet & Markus Jaritz & Annelie Wuensche & Erika Schirghuber & Iain Finley Davidson & Wen Tang & David A. Cisneros & Venugopal Bhaskara & Tomoko Nishiyama & , 2013. "Wapl is an essential regulator of chromatin structure and chromosome segregation," Nature, Nature, vol. 501(7468), pages 564-568, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7468:d:10.1038_nature12471
    DOI: 10.1038/nature12471
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature12471
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature12471?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ryuichiro Nakato & Toyonori Sakata & Jiankang Wang & Luis Augusto Eijy Nagai & Yuya Nagaoka & Gina Miku Oba & Masashige Bando & Katsuhiko Shirahige, 2023. "Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Daniel Bsteh & Hagar F. Moussa & Georg Michlits & Ramesh Yelagandula & Jingkui Wang & Ulrich Elling & Oliver Bell, 2023. "Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Aayush Kant & Zixian Guo & Vinayak Vinayak & Maria Victoria Neguembor & Wing Shun Li & Vasundhara Agrawal & Emily Pujadas & Luay Almassalha & Vadim Backman & Melike Lakadamyali & Maria Pia Cosma & Viv, 2024. "Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    4. Louisa Hill & Gordana Wutz & Markus Jaritz & Hiromi Tagoh & Lesly Calderón & Jan-Michael Peters & Anton Goloborodko & Meinrad Busslinger, 2023. "Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:501:y:2013:i:7468:d:10.1038_nature12471. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.