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Wapl is an essential regulator of chromatin structure and chromosome segregation

Author

Listed:
  • Antonio Tedeschi

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Gordana Wutz

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Sébastien Huet

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany
    CNRS, UMR 6290, Institut Génétique et Développement de Rennes, F-35043 Rennes, France
    Université de Rennes 1, Université Européenne de Bretagne, Structure fédérative de recherche Biosit, Faculté de Médecine, F-35043 Rennes, France)

  • Markus Jaritz

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Annelie Wuensche

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany)

  • Erika Schirghuber

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Iain Finley Davidson

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • Wen Tang

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

  • David A. Cisneros

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Max F. Perutz Laboratories, University of Vienna, Austria, Dr. Bohr-Gasse 9, 1030 Vienna, Austria
    Research Platform Quantum Phenomena & Nanoscale Biological Systems (QuNaBioS), University of Vienna, Dr. Bohr-Gasse 7-9, 1030 Vienna, Austria)

  • Venugopal Bhaskara

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Tomoko Nishiyama

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Alipasha Vaziri

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Max F. Perutz Laboratories, University of Vienna, Austria, Dr. Bohr-Gasse 9, 1030 Vienna, Austria
    Research Platform Quantum Phenomena & Nanoscale Biological Systems (QuNaBioS), University of Vienna, Dr. Bohr-Gasse 7-9, 1030 Vienna, Austria)

  • Anton Wutz

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria
    Present addresses: CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, AKH BT 25.3, 1090 Vienna, Austria (E.S.); Eucodis Bioscience GmbH, Campus Vienna Biocenter 2, 2. OG Viehmarktgasse 2A, 1030 Vienna, Austria (V.B.); Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan (T.N.); Institute of Molecular Health Sciences, ETH Zürich, Schafmattstrasse 22, 8093 Zürich, Switzerland (A.W.).)

  • Jan Ellenberg

    (Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstr. 1, Heidelberg 69117, Germany)

  • Jan-Michael Peters

    (Research Institute of Molecular Pathology (I.M.P.), Dr. Bohr-Gasse 7, 1030 Vienna, Austria)

Abstract

Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes; the findings suggest that cohesin could have an architectural role in interphase chromosome organization.

Suggested Citation

  • Antonio Tedeschi & Gordana Wutz & Sébastien Huet & Markus Jaritz & Annelie Wuensche & Erika Schirghuber & Iain Finley Davidson & Wen Tang & David A. Cisneros & Venugopal Bhaskara & Tomoko Nishiyama & , 2013. "Wapl is an essential regulator of chromatin structure and chromosome segregation," Nature, Nature, vol. 501(7468), pages 564-568, September.
    • Handle: RePEc:nat:nature:v:501:y:2013:i:7468:d:10.1038_nature12471
    DOI: 10.1038/nature12471
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    Citations

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    Cited by:

    1. Ryuichiro Nakato & Toyonori Sakata & Jiankang Wang & Luis Augusto Eijy Nagai & Yuya Nagaoka & Gina Miku Oba & Masashige Bando & Katsuhiko Shirahige, 2023. "Context-dependent perturbations in chromatin folding and the transcriptome by cohesin and related factors," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Daniel Bsteh & Hagar F. Moussa & Georg Michlits & Ramesh Yelagandula & Jingkui Wang & Ulrich Elling & Oliver Bell, 2023. "Loss of cohesin regulator PDS5A reveals repressive role of Polycomb loops," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Natalia Pardo-Lorente & Anestis Gkanogiannis & Luca Cozzuto & Antoni Gañez Zapater & Lorena Espinar & Ritobrata Ghose & Jacqueline Severino & Laura García-López & Rabia Gül Aydin & Laura Martin & Mari, 2024. "Nuclear localization of MTHFD2 is required for correct mitosis progression," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
    4. Aayush Kant & Zixian Guo & Vinayak Vinayak & Maria Victoria Neguembor & Wing Shun Li & Vasundhara Agrawal & Emily Pujadas & Luay Almassalha & Vadim Backman & Melike Lakadamyali & Maria Pia Cosma & Viv, 2024. "Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    5. Louisa Hill & Gordana Wutz & Markus Jaritz & Hiromi Tagoh & Lesly Calderón & Jan-Michael Peters & Anton Goloborodko & Meinrad Busslinger, 2023. "Igh and Igk loci use different folding principles for V gene recombination due to distinct chromosomal architectures of pro-B and pre-B cells," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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